{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:00:56Z","timestamp":1790431256602,"version":"4.1.0"},"reference-count":14,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":["online.boneandjoint.org.uk"],"crossmark-restriction":true},"short-container-title":["The Bone &amp; Joint Journal"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p> There is currently limited information available on the benefits and risks of extended thromboprophylaxis after hip fracture surgery. SAVE-HIP3 was a randomised, double-blind study conducted to evaluate the efficacy and safety of extended thromboprophylaxis with the ultra-low molecular-weight heparin semuloparin compared with placebo in patients undergoing hip fracture surgery. After a seven- to ten-day open-label run-in phase with semuloparin (20 mg once daily subcutaneously, initiated post-operatively), patients were randomised to once-daily semuloparin (20\u00a0mg subcutaneously) or placebo for 19 to 23\u00a0additional days. The primary efficacy endpoint was a composite of any venous thromboembolism (VTE; any deep-vein thrombosis and non-fatal pulmonary embolism) or all-cause death until day 24 of the double-blind period. Safety parameters included major and clinically relevant non-major bleeding, laboratory data, and treatment-emergent adverse events (TEAEs). Extended thromboprophylaxis with semuloparin demonstrated a relative risk reduction of 79% in the rate of any VTE or all-cause death compared with placebo (3.9% vs 18.6%, respectively; odds ratio 0.18 (95% confidence interval 0.07 to 0.45), p &lt; 0.001). Two patients in the semuloparin group and none in the placebo group experienced clinically relevant bleeding. TEAE rates were similar in both groups. In conclusion, the SAVE-HIP3 study results demonstrate that patients undergoing hip fracture surgery benefit from extended thromboprophylaxis. <\/jats:p><jats:p> Cite this article: Bone Joint J 2013;95-B:459\u201366. <\/jats:p>","DOI":"10.1302\/0301-620x.95b4.30730","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T10:38:15Z","timestamp":1364467095000},"page":"459-466","update-policy":"https:\/\/doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Extended venous thromboembolism prophylaxis in patients undergoing hip fracture surgery \u2013 the SAVE-HIP3 study"],"prefix":"10.1302","volume":"95-B","author":[{"given":"W. D.","family":"Fisher","sequence":"first","affiliation":[{"name":"McGill University Health Centre, 1650\rCedar Avenue, Bureau B5.158.7, Montreal, Quebec\rH3G 1A4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Agnelli","sequence":"additional","affiliation":[{"name":"University of Perugia, Department\rof Internal and Cardiovascular Medicine and Stroke Unit, 06132\rPerugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"George","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Box\r102002, Durham, North\rCarolina 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Thrombosis Research Institute and University\rCollege London, Emmanuel Kaye Building, Manresa\rRoad, London SW3 6LR, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Lassen","sequence":"additional","affiliation":[{"name":"Spine Center Copenhagen, Clinical\rTrial Unit, Copenhagen University Hospital, Glostrup\rDK-2600, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mismetti","sequence":"additional","affiliation":[{"name":"B\u00e2timent Recherche \u2013 H\u00f4pital Nord, CHU\rde St Etienne. 42055 St Etienne, Cedex 2, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mouret","sequence":"additional","affiliation":[{"name":"Klinikum Frankfurt H\u00f6chst GmbH, Gotenstrasse\r6-8, Frankfurt 65929, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G. G.","family":"Turpie","sequence":"additional","affiliation":[{"name":"Hamilton Health Sciences, General\rHospital, 237 Barton Street, East\rHamilton, Ontario L8L 2X2, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"r1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00003086-198103000-00003","volume":"155","author":"Snook GA","year":"1981","journal-title":"Clin Orthop Relat Res"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648413"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0656"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011100"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2404"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.11.1337"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03447.x"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03301.x"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04701.x"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"r11","unstructured":"No authors listed. ICH (1996) Guidance for Industry. E6 Good Clinical Practice: Consolidated Guidance. Geneva, Switzerland: International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. http:\/\/www.ich.org\/products\/guidelines\/efficacy\/article\/efficacy-guidelines.html (date last accessed 14 February 2013)."},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1972.04180020014004"},{"key":"r13","first-page":"471","volume":"57","author":"Gart JJ","year":"1970","journal-title":"Biometrika"},{"key":"r14","unstructured":"No authors listed. European Medicines Agency. Draft guideline on clinical investigation of medicinal products for prevention of venous thromboembolism (VTE) in patients undergoing high VTE-risk surgery. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2012\/05\/WC500127902.pdf (date last accessed 8 January 2013)."}],"container-title":["The Bone &amp; Joint Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.95B4.30730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/0301-620X.95B4.30730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.95B4.30730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T22:17:15Z","timestamp":1634595435000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.95B4.30730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1302\/0301-620X.95B4.30730"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.95b4.30730","relation":{},"ISSN":["2049-4394","2049-4408"],"issn-type":[{"value":"2049-4394","type":"print"},{"value":"2049-4408","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"2012-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}