{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:05:28Z","timestamp":1778655928226,"version":"3.51.4"},"reference-count":34,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":["online.boneandjoint.org.uk"],"crossmark-restriction":true},"short-container-title":["The Bone &amp; Joint Journal"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p> Our understanding of the origin of hip pain in degenerative disorders of the hip, including primary osteoarthritis, avascular necrosis and femoroacetabular impingement (FAI), is limited. We undertook a histological investigation of the nociceptive innervation of the acetabular labrum, ligamentum teres and capsule of the hip, in order to prove pain- and proprioceptive-associated marker expression. These structures were isolated from 57 patients who had undergone elective hip surgery (44 labral samples, 33 ligamentum teres specimens, 34 capsular samples; in 19 patients all three structures were harvested). A total of 15\u00a0000 histological sections were prepared that were investigated immunohistochemically for the presence of protein S-100, 68 kDa neurofilament, neuropeptide Y, nociceptin and substance P. The tissues were evaluated in six representative areas. <\/jats:p><jats:p> Within the labrum, pain-associated free nerve ending expression was located predominantly at its base, decreasing in the periphery. In contrast, the distribution within the ligamentum teres showed a high local concentration in the centre. The hip capsule had an almost homogeneous marker expression in all investigated areas. <\/jats:p><jats:p> This study showed characteristic distribution profiles of nociceptive and pain-related nerve fibres, which may help in understanding the origin of hip pain. <\/jats:p><jats:p> Cite this article: Bone Joint J 2013;95-B:770\u20136. <\/jats:p>","DOI":"10.1302\/0301-620x.95b6.30262","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T08:42:50Z","timestamp":1369903370000},"page":"770-776","update-policy":"https:\/\/doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":84,"title":["The distribution of nociceptive innervation in the painful hip"],"prefix":"10.1302","volume":"95-B","author":[{"given":"M.","family":"Haversath","sequence":"first","affiliation":[{"name":"University Hospital of Duisburg-Essen, Department\rof Orthopaedics, Hufelandstrasse 55, D-45147\rEssen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hanke","sequence":"additional","affiliation":[{"name":"University Hospital of Duisburg-Essen, Department\rof Orthopaedics, Hufelandstrasse 55, D-45147\rEssen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Landgraeber","sequence":"additional","affiliation":[{"name":"University Hospital of Duisburg-Essen, Department\rof Orthopaedics, Hufelandstrasse 55, D-45147\rEssen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Herten","sequence":"additional","affiliation":[{"name":"University Hospital of Duesseldorf, Department\rof Orthopaedics, Moorenstrasse 5, D-40225\rDuesseldorf, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zilkens","sequence":"additional","affiliation":[{"name":"University Hospital of Duesseldorf, Department\rof Orthopaedics, Moorenstrasse 5, D-40225\rDuesseldorf, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Krauspe","sequence":"additional","affiliation":[{"name":"University Hospital of Duesseldorf, Department\rof Orthopaedics, Moorenstrasse 5, D-40225\rDuesseldorf, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"University Hospital of Duisburg-Essen, Department\rof Orthopaedics, Hufelandstrasse 55, D-45147\rEssen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199906000-00012"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.5301\/HIP.2012.9748"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.70B1.3339061"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B8.20161"},{"key":"r5","doi-asserted-by":"crossref","unstructured":"Uhthoff HK, Jarvis J. 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