{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:47:26Z","timestamp":1791312446496,"version":"4.3.1"},"reference-count":13,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":["online.boneandjoint.org.uk"],"crossmark-restriction":true},"short-container-title":["The Bone &amp; Joint Journal"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>The management of failed autologous chondrocyte implantation (ACI) and matrix-assisted autologous chondrocyte implantation (MACI) for the treatment of symptomatic osteochondral defects in the knee represents a major challenge. Patients are young, active and usually unsuitable for prosthetic replacement. This study reports the results in patients who underwent revision cartilage transplantation of their original ACI\/MACI graft for clinical or graft-related failure. We assessed 22 patients (12 men and 10 women) with a mean age of 37.4 years (18 to 48) at a mean of 5.4 years (1.3 to 10.9). The mean period between primary and revision grafting was 46.1 months (7 to 89). The mean defect size was 446.6 mm<jats:sup>2<\/jats:sup>(150 to 875) and they were located on 11 medial and two lateral femoral condyles, eight patellae and one trochlea.<\/jats:p><jats:p>The mean modified Cincinnati knee score improved from 40.5 (16 to 77) pre-operatively to 64.9 (8 to 94) at their most recent review (p &lt; 0.001). The visual analogue pain score improved from 6.1 (3 to 9) to 4.7 (0 to 10) (p = 0.042). A total of 14 patients (63%) reported an \u2018excellent\u2019 (n = 6) or \u2018good\u2019 (n = 8) clinical outcome, 5 \u2018fair\u2019 and one \u2018poor\u2019 outcome. Two patients underwent patellofemoral joint replacement. This study demonstrates that revision cartilage transplantation after primary ACI and MACI can yield acceptable functional results and continue to preserve the joint.<\/jats:p><jats:p>Cite this article: Bone Joint J 2014;96-B:54\u20138.<\/jats:p>","DOI":"10.1302\/0301-620x.96b1.31979","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T10:23:46Z","timestamp":1389003826000},"page":"54-58","update-policy":"https:\/\/doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Revision cartilage cell transplantation for failed autologous chondrocyte transplantation in chronic osteochondral defects of the knee"],"prefix":"10.1302","volume":"96-B","author":[{"given":"S.","family":"Vijayan","sequence":"first","affiliation":[{"name":"Royal National Orthopaedic Hospital, Joint Reconstruction and Cartilage Transplantation Unit, Brockley Hill, Stanmore HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bentley","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Joint Reconstruction and Cartilage Transplantation Unit, Brockley Hill, Stanmore HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Joint Reconstruction and Cartilage Transplantation Unit, Brockley Hill, Stanmore HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W. R.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Joint Reconstruction and Cartilage Transplantation Unit, Brockley Hill, Stanmore HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Joint Reconstruction and Cartilage Transplantation Unit, Brockley Hill, Stanmore HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W. J.","family":"Carrington","sequence":"additional","affiliation":[{"name":"Royal National Orthopaedic Hospital, Joint Reconstruction and Cartilage Transplantation Unit, Brockley Hill, Stanmore HA7 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"r2","first-page":"353","volume":"87","author":"Bartlett W","year":"2005","journal-title":"J Bone Joint Surg [Br]"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.65136"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B1.16796"},{"key":"r5","unstructured":"No authors listed.National Institute of Clinical Excellence. Guidance on the use of autologous chondrocyte transplantation for full thickness cartilage defects in knee joints: technology appraisal guidance No. 16. 2000. http:\/\/www.nice.org.uk\/nicemedia\/pdf\/guidanceactknee.pdf (date last accessed 9 September 2013)."},{"key":"r6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00003086-198909000-00034","volume":"246","author":"Noyes FR","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B6.0800965"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B2.13543"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.02.011"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B4.27495"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B4.27117"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200110000-00003"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B12.22879"}],"container-title":["The Bone &amp; Joint Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.96B1.31979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/0301-620X.96B1.31979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.96B1.31979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T16:07:00Z","timestamp":1647878820000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.96B1.31979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1302\/0301-620X.96B1.31979"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.96b1.31979","relation":{},"ISSN":["2049-4394","2049-4408"],"issn-type":[{"value":"2049-4394","type":"print"},{"value":"2049-4408","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2013-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}