{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:14:53Z","timestamp":1792430093133,"version":"4.5.0"},"reference-count":33,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":["online.boneandjoint.org.uk"],"crossmark-restriction":true},"short-container-title":["The Bone &amp; Joint Journal"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>We retrospectively reviewed 30 patients with a diffuse-type giant-cell tumour (Dt-GCT) (previously known as pigmented villonodular synovitis) around the knee in order to assess the influence of the type of surgery on the functional outcome and quality of life (QOL). Between 1980 and 2001, 15 of these tumours had been treated primarily at our tertiary referral centre and 15 had been referred from elsewhere with recurrent lesions.<\/jats:p><jats:p>The mean follow-up was 64 months (24 to 393). Functional outcome and QOL were assessed with range of movement and the Knee injury and Osteoarthritis Outcome Score (KOOS), the Musculoskeletal Tumour Society (MSTS) score, the Toronto Extremity Salvage Score (TESS) and the SF-36 questionnaire. There was recurrence in four of 14 patients treated initially by open synovectomy. Local control was achieved after a second operation in 13 of 14 (93%). Recurrence occurred in 15 of 16 patients treated initially by arthroscopic synovectomy. These patients underwent a mean of 1.8 arthroscopies (one to eight) before open synovectomy. This achieved local control in 8 of 15 (53%) after the first synovectomy and in 12 of 15 (80%) after two. The functional outcome and QOL of patients who had undergone primary arthroscopic synovectomy and its attendant subsequent surgical procedures were compared with those who had had a primary open synovectomy using the\u00a0following measures: range of movement (114\u00ba versus 127\u00ba; p = 0.03); KOOS (48 versus 71; p = 0.003); MSTS (19 versus 24; p = 0.02); TESS (75 versus 86; p = 0.03); and SF-36 (62\u00a0versus 80; p = 0.01).<\/jats:p><jats:p>Those who had undergone open synovectomy needed fewer subsequent operations. Most patients who had been referred with a recurrence had undergone an initial arthroscopic synovectomy followed by multiple further synovectomies. At the final follow-up of eight years (2 to 32), these patients had impaired function and QOL compared with those who had undergone open synovectomy initially.<\/jats:p><jats:p>We conclude that the natural history of Dt-GCT in patients who are treated by arthroscopic synovectomy has an unfavourable outcome, and that primary open synovectomy should be undertaken to prevent recurrence or residual disease.<\/jats:p><jats:p>Cite this article: Bone Joint J 2014; 96-B:1111\u201318.<\/jats:p>","DOI":"10.1302\/0301-620x.96b8.33608","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T09:54:01Z","timestamp":1406886841000},"page":"1111-1118","update-policy":"https:\/\/doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["Functional outcome and quality of life after the surgical treatment for diffuse-type giant-cell tumour around the knee"],"prefix":"10.1302","volume":"96-B","author":[{"given":"L.","family":"van der Heijden","sequence":"first","affiliation":[{"name":"Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. L.","family":"Mastboom","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D. S.","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A. J.","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"r1","unstructured":"de St. Aubain Somerhausen N, van de Rijn M. Tenosynovial giant cell tumour, diffuse\/localized type. In: Fletcher CD, Bridge JA, Hogendoorn PC, Mertens F, eds. WHO Classification of Tumours of Soft Tissue and Bone . Vol. 5, 4th ed. Lyon: IARC Press, 2013:100\u2013103."},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507321103"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21835"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B7.28927"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2288-5"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23220"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2001.24068"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(03)00127-0"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2011.12.002"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200211000-00049"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2589-8"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1053\/ar.1999.v15.015061"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2009.01.007"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-16"},{"key":"r15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00003086-199301000-00035","volume":"286","author":"Enneking WF","year":"1993","journal-title":"Clin Orthop Relat Res"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199901000-00012"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00097-3"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26529"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000224051.01873.fb"},{"key":"r20","first-page":"1197","volume":"29","author":"Ozturk H","year":"2008","journal-title":"Saudi Med J"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.10.014"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2007.03.012"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200212000-00011"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000079263.91782.4d"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2589-8"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1007\/s004020050009"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.10.1113"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.3944\/AOTT.2011.2442"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1747-y"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-008-9104-5"},{"key":"r32","unstructured":"Liu C, Zhao J, Chen L. [Clinical results of arthroscopic treatment for localized pigmented villonodular synovitis of knee]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2009;23:1042\u20131044 [Article in Chinese]."},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-38"}],"container-title":["The Bone &amp; Joint Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.96B8.33608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/0301-620X.96B8.33608","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/0301-620X.96B8.33608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:03:10Z","timestamp":1649847790000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/0301-620X.96B8.33608"}},"subtitle":["A retrospective analysis of 30 patients"],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1302\/0301-620X.96B8.33608"],"URL":"https:\/\/doi.org\/10.1302\/0301-620x.96b8.33608","relation":{},"ISSN":["2049-4394","2049-4408"],"issn-type":[{"value":"2049-4394","type":"print"},{"value":"2049-4408","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"2013-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}