{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:52:28Z","timestamp":1787021548029,"version":"build-2736575974"},"reference-count":22,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/online.boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":["online.boneandjoint.org.uk"],"crossmark-restriction":true},"short-container-title":["Bone &amp; Joint Research"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Osteoporosis and abnormal bone metabolism may prove to be significant factors influencing the outcome of arthroplasty surgery, predisposing to complications of aseptic loosening and peri-prosthetic fracture. We aimed to investigate baseline bone mineral density (BMD) and bone turnover in patients about to undergo arthroplasty of the hip and knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively measured bone mineral density of the hip and lumbar spine using dual-energy X-ray absorptiometry (DEXA) scans in a cohort of 194 patients awaiting hip or knee arthroplasty. We also assessed bone turnover using urinary deoxypyridinoline (DPD), a type I collagen crosslink, normalised to creatinine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of DEXA proven hip osteoporosis (T-score \u2264 -2.5) among hip and knee arthroplasty patients was found to be low at 2.8% (4 of 143). Spinal osteoporosis prevalence was higher at 6.9% (12 of 175). Sixty patients (42% (60 of 143)) had osteopenia or osteoporosis of either the hip or spine. The mean T-score for the hip was -0.34 (sd 1.23), which is within normal limits, and the mean hip Z-score was positive at 0.87 (sd 1.17), signifying higher-than-average BMD for age. The median urinary DPD\/creatinine was raised in both female patients at 8.1 (interquartile range (IQR) 6.6 to 9.9) and male patients at 6.2 (IQR 4.8 to 7.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results indicate hip and knee arthroplasty patients have higher BMD of the hip and spine compared with an age-matched general population, and a lower prevalence of osteoporosis. However, untreated osteoporotic patients are undergoing arthroplasty, which may negatively impact their outcome. Raised DPD levels suggest abnormal bone turnover, requiring further investigation. Cite this article: Bone Joint Res 2014;3:14\u201319.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1302\/2046-3758.31.2000218","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T23:02:00Z","timestamp":1389999720000},"page":"14-19","update-policy":"https:\/\/doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Baseline bone mineral density and bone turnover in pre-operative hip and knee arthroplasty patients"],"prefix":"10.1302","volume":"3","author":[{"given":"S. J.","family":"James","sequence":"first","affiliation":[{"name":"Southampton University Hospital, Department\rof Trauma and Orthopaedic Surgery, Tremona\rRoad, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Mirza","sequence":"additional","affiliation":[{"name":"Southampton University Hospital, Department\rof Trauma and Orthopaedic Surgery, Tremona\rRoad, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Culliford","sequence":"additional","affiliation":[{"name":"University of Southampton, Faculty\rof Medicine, Highfield Campus, University\rRoad, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Southampton University Hospital, Osteoporosis\rCentre, Tremona Road, Southampton SO16\r6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Carr","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical\rResearch Unit, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. K.","family":"Arden","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical\rResearch Unit, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"42","reference":[{"key":"r1","unstructured":"No authors listed.\n                      National Joint Registry 9th Annual Report. National Joint Registry for England and Wales, 2012. http:\/\/www.njrcentre.org.uk\/njrcentre\/Reports,PublicationsandMinutes\/tabid\/85\/Default.aspx (date last accessed 4 October 2013)."},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B1.22654"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1204-0"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00155"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.3109\/17453679308993679"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(05)70074-2"},{"key":"r7","first-page":"154","volume":"65","author":"van Loon CJ","year":"1999","journal-title":"Acta Orthop Belg"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380706"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361205"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.12.1299"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1002\/art.22088"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1002\/art.11380"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d7222"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2013.797313"},{"key":"r15","unstructured":"No authors listed.\n                      World Health Organization: prevention and management of osteoporosis. http:\/\/whqlibdoc.who.int\/trs\/who_trs_921.pdf (date last accessed 9 December 2013)."},{"key":"r16","unstructured":"Delmas PD.\n                      Biochemical markers for the assessment of bone turnover. In: Riggs BL, Melton L, eds.\n                      Osteoporosis: etiology, diagnosis and management\n                      . Philadelphia: Lippincott-Raven, 1995:319\u2013333."},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080516"},{"key":"r18","unstructured":"No authors listed.\n                      Siemens Immulite. http:\/\/www.medical.siemens.com\/siemens\/en_GLOBAL\/gg_diag_FBAs\/files\/package_inserts\/immulite\/Bone_Metabolism_n\/pilkpd-11.pdf (date last accessed 9 December 2013)."},{"key":"r19","unstructured":"No authors listed.\n                      Clinical Chemistry. http:\/\/www.clinchem.org\/content\/42\/12\/2037.full.pdf+html (date last accessed 9 December 2013)."},{"key":"r20","first-page":"527","volume":"27","author":"Yu SL","year":"1998","journal-title":"Ann Acad Med Singapore"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00381-1"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.2.297"}],"container-title":["Bone &amp; Joint Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/2046-3758.31.2000218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/2046-3758.31.2000218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/2046-3758.31.2000218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T16:27:14Z","timestamp":1634660834000},"score":1,"resource":{"primary":{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/10.1302\/2046-3758.31.2000218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1302\/2046-3758.31.2000218"],"URL":"https:\/\/doi.org\/10.1302\/2046-3758.31.2000218","relation":{},"ISSN":["2046-3758"],"issn-type":[{"value":"2046-3758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2013-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}