{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:22:41Z","timestamp":1788823361539,"version":"build-2803163510"},"reference-count":55,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":3209,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Most of tumours of the foot are tumour-like (synovial cyst, foreign body reactions and epidermal inclusion cyst) or benign conditions (tenosynovial giant cells tumours, planta fibromatosis). Malignant tumours of the soft-tissue and skeleton are very rare in the foot and their diagnosis is often delayed with referral to specialised teams after initial inappropriate procedures or unplanned excisions. The adverse effect of these misdiagnosed tumours is the increasing rate of amputation or local recurrences in the involved patients. In every lump, imaging should be discussed before any local treatment. Every lesion which is not an obvious synovial cyst or plantar fibromatosis should have a biopsy performed. After the age of 40 years, chondrosarcoma is the most usual malignant tumour of the foot. In young patients bone tumours such as osteosarcoma or Ewing\u2019s sarcoma, are very unusually located in the foot. Synovial sarcoma is the most frequent histological diagnosis in soft tissues. Epithelioid sarcoma or clear cell sarcoma, involve more frequently the foot and ankle than other sites. The classic local treatment of malignant conditions of the foot and ankle was below-knee amputation at different levels. Nowadays, with the development of adjuvant therapies, some patients may benefit from conservative surgery or partial amputation after multidisciplinary team discussions. The prognosis of foot malignancy is not different from that at other locations, except perhaps in chondrosarcoma, which seems to be less aggressive in the foot. The anatomy of the foot is very complex with many bony and soft tissue structures in a relatively small space making large resections and conservative treatments difficult to achieve.<\/jats:p>\n                  <jats:p>Cite this article: EFORT Open Rev 2017;2. DOI: 10.1302\/2058-5241.2.160078. Originally published online at www.efortopenreviews.org<\/jats:p>","DOI":"10.1302\/2058-5241.2.160078","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T20:10:42Z","timestamp":1494533442000},"page":"261-271","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":42,"title":["Malignant tumours of the foot and ankle"],"prefix":"10.1530","volume":"2","author":[{"given":"E.","family":"Mascard","sequence":"first","affiliation":[{"name":"1Necker University Hospital, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gaspar","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Brugi\u00e8res","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Glorion","sequence":"additional","affiliation":[{"name":"3Orthopedic Surgery Department, Necker University Hospital, 149 rue de S\u00e8vres, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pannier","sequence":"additional","affiliation":[{"name":"3Orthopedic Surgery Department, Necker University Hospital, 149 rue de S\u00e8vres, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gomez-Brouchet","sequence":"additional","affiliation":[{"name":"4Laboratoire d'anatomie et cytologie pathologiques, Institut Universitaire du Cancer de Toulouse- Oncopole, 1 avenue Ir\u00e8ne Joliot-Curie. 31059 Toulouse Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"2026070711192693800_bibr1-2058-5241.2.160078","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2106\/00004623-198971040-00018","article-title":"Soft-tissue tumors and tumor-like lesions of the foot. 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