{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:26:26Z","timestamp":1783441586157,"version":"3.54.6"},"reference-count":26,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":2175,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Total hip arthroplasty (THA) in sickle cell disease (SCD) patients can be a challenging procedure. This systematic review evaluated the revision rate, functional outcomes and complications of THA in sicklers. A systematic search was conducted according to the PRISMA guidelines, using four search engines from inception to May 2019. Fifteen studies with 971 THAs were included. There were 437 cemented and 520 uncemented THAs. There were 164 revision THAs (16.8%); 52 uncemented and 105 cemented THAs. Forty-two infections were recorded; 16 infections for cemented and 23 for uncemented THAs. Fifty-seven cups, 26 stems, eight cup\/stem with aseptic loosening that were more frequently cemented were reported. The 28 unspecified aseptic loosening cases were more frequently uncemented THAs. All studies demonstrated the functional improvement of patients. There were 109 medical complications (14.3%). Sickle cell crises (SCC) and transfusion reactions were most usually recorded. Forty-six intraoperative complications (4.7%) were reported; 18 femoral fractures, four acetabular and 18 femoral perforations. Seventeen femoral fractures occurred during uncemented THA. THA in SCD is still related to a high risk of complications. The outcomes in properly selected sicklers have been improved. Perioperative adequate hydration, warming, oxygen supply and transfusion protocols are mandated to prevent SCC and transfusion reactions. The surgeon must be prepared to deal with a high rate of intraoperative fractures and have different implant options readily available. No definite conclusion can be made regarding the best fixation mode. Cemented implants demonstrated a higher revision rate and uncemented implants a higher risk for intraoperative complications.<\/jats:p>\n                  <jats:p>Cite this article: EFORT Open Rev 2020;5:180-188. DOI: 10.1302\/2058-5241.5.190038<\/jats:p>","DOI":"10.1302\/2058-5241.5.190038","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T05:11:53Z","timestamp":1583125913000},"page":"180-188","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":30,"title":["Total hip arthroplasty in sickle cell disease: a systematic review"],"prefix":"10.1530","volume":"5","author":[{"given":"Eustathios","family":"Kenanidis","sequence":"first","affiliation":[{"name":"1Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece"},{"name":"2Center of Orthopaedics and Regenerative Medicine (C.O.RE.) \u2013 Center of Interdisciplinary Research and Innovation (C.I.R.I.) \u2013 Aristotle University Thessaloniki, Balkan Center, Hellas, Greece"},{"name":"3H\u00f4pital de la Tour, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kapriniotis","sequence":"additional","affiliation":[{"name":"2Center of Orthopaedics and Regenerative Medicine (C.O.RE.) \u2013 Center of Interdisciplinary Research and Innovation (C.I.R.I.) \u2013 Aristotle University Thessaloniki, Balkan Center, Hellas, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Anagnostis","sequence":"additional","affiliation":[{"name":"2Center of Orthopaedics and Regenerative Medicine (C.O.RE.) \u2013 Center of Interdisciplinary Research and Innovation (C.I.R.I.) \u2013 Aristotle University Thessaloniki, Balkan Center, Hellas, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Potoupnis","sequence":"additional","affiliation":[{"name":"1Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece"},{"name":"2Center of Orthopaedics and Regenerative Medicine (C.O.RE.) \u2013 Center of Interdisciplinary Research and Innovation (C.I.R.I.) \u2013 Aristotle University Thessaloniki, Balkan Center, Hellas, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Christofilopoulos","sequence":"additional","affiliation":[{"name":"3H\u00f4pital de la Tour, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Tsiridis","sequence":"additional","affiliation":[{"name":"1Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece"},{"name":"2Center of Orthopaedics and Regenerative Medicine (C.O.RE.) \u2013 Center of Interdisciplinary Research and Innovation (C.I.R.I.) \u2013 Aristotle University Thessaloniki, Balkan Center, Hellas, 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