{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:18:17Z","timestamp":1783444697348,"version":"3.54.6"},"reference-count":36,"publisher":"Bioscientifica","issue":"8","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":1657,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Elderly hip fracture patients are at risk of stress-related gastric mucosal damage, and upper gastrointestinal bleeding is one of the underrecognized but devastating complications. Proton pump inhibitors (PPIs) offer effective prophylaxis against stress-related gastric mucosal damage. Systematic analysis of the literature revealed numerous articles on PPIs and hip fractures, but only three articles dedicated to the analysis of prophylactic use of PPIs in patients with a hip fracture. There is significant reduction in upper gastrointestinal bleeding following PPI prophylaxis and reduced 90-day mortality in elderly hip fracture patients on prophylaxis. PPIs are generally safe, cost-effective and based on available evidence. Their prophylactic use is justifiable in elderly patients with hip fractures. We suggest that PPIs be prescribed routinely peri-operatively in elderly hip fracture patients. Further level-one studies on the subject will allow for firmer recommendations.<\/jats:p>\n                  <jats:p>Cite this article: EFORT Open Rev 2021;6:686-691. DOI: 10.1302\/2058-5241.6.200053<\/jats:p>","DOI":"10.1302\/2058-5241.6.200053","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T09:56:39Z","timestamp":1628589399000},"page":"686-691","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":6,"title":["Should we routinely prescribe proton pump inhibitors peri-operatively in elderly patients with hip fractures? A review of the literature"],"prefix":"10.1530","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-8517","authenticated-orcid":false,"given":"Mabua A.","family":"Chuene","sequence":"first","affiliation":[{"name":"1Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurek R.T.","family":"Pietrzak","sequence":"additional","affiliation":[{"name":"1Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-6500","authenticated-orcid":false,"given":"Allan R.","family":"Sekeitto","sequence":"additional","affiliation":[{"name":"1Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipalo","family":"Mokete","sequence":"additional","affiliation":[{"name":"1Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"2026070711354775700_bibr1-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0310057X1204000207","article-title":"Prevention of gastrointestinal bleeding due to stress ulceration: a review of current literature","volume":"40","author":"Pilkington","year":"2012","journal-title":"Anaesth Intensive Care"},{"key":"2026070711354775700_bibr2-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/CCM.0b013e3182758734","article-title":"Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis","volume":"41","author":"Alhazzani","year":"2013","journal-title":"Crit Care Med"},{"key":"2026070711354775700_bibr3-2058-5241.6.200053","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.38643.663843.55","article-title":"Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study","volume":"331","author":"Roche","year":"2005","journal-title":"BMJ"},{"key":"2026070711354775700_bibr4-2058-5241.6.200053","unstructured":"NICE guidelines.\n          www.nice.org.uk\/guidance\/cg124 (date last accessed 28 November 2020)."},{"key":"2026070711354775700_bibr5-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph16091571","article-title":"Proton pump inhibitors and fracture risk: a review of current evidence and mechanisms involved","volume":"16","author":"Thong","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"2026070711354775700_bibr6-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/imj.13809","article-title":"Upper gastrointestinal bleeding in neck of femur fracture patients: a single tertiary centre experience","volume":"48","author":"Liu","year":"2018","journal-title":"Intern Med J"},{"key":"2026070711354775700_bibr7-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2036.2006.03187.x","article-title":"Perioperative acute upper gastrointestinal haemorrhage in older patients with hip fracture: incidence, risk factors and prevention","volume":"25","author":"Fisher","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"2026070711354775700_bibr8-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/1120700019832603","article-title":"Pre-fracture medication use as a predictor of 30-day mortality in hip fracture patients: an analysis of 141,201 patients","volume":"30","author":"Jantzen","year":"2020","journal-title":"Hip Int"},{"key":"2026070711354775700_bibr9-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/cc13780","article-title":"Stress ulceration: prevalence, pathology and association with adverse outcomes","volume":"18","author":"Plummer","year":"2014","journal-title":"Crit Care"},{"key":"2026070711354775700_bibr10-2058-5241.6.200053","volume-title":"Acute medicine: a practical guide to the management of medical emergencies","author":"Ostermann","year":"2017","edition":"5th ed."},{"key":"2026070711354775700_bibr11-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1308\/rcsann.2016.0106","article-title":"Prophylactic proton pump inhibitors in femoral neck fracture patients: a life- and cost-saving intervention","volume":"98","author":"Singh","year":"2016","journal-title":"Ann R Coll Surg Engl"},{"key":"2026070711354775700_bibr12-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1097\/CCM.0000000000001157","article-title":"Protocols and hospital mortality in critically ill patients: the United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study","volume":"43","author":"Sevransky","year":"2015","journal-title":"Crit Care Med"},{"key":"2026070711354775700_bibr13-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/CCM.0000000000002461","article-title":"Withholding Pantoprazole for stress ulcer prophylaxis in critically ill patients: a plot randomized clinical trial and meta-analysis","volume":"45","author":"Alhazzani","year":"2017","journal-title":"Crit Care Med"},{"key":"2026070711354775700_bibr14-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/cc709","article-title":"Understanding gastrointestinal perfusion in critical care: so near, and yet so far","volume":"4","author":"Ackland","year":"2000","journal-title":"Crit Care"},{"key":"2026070711354775700_bibr15-2058-5241.6.200053","first-page":"329","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiolog Rep"},{"key":"2026070711354775700_bibr16-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2147\/JMDH.S54324","article-title":"Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment","volume":"7","author":"Cryer","year":"2014","journal-title":"J Multidiscip Healthc"},{"key":"2026070711354775700_bibr17-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00003246-198607000-00001","article-title":"Does nasoenteral feeding afford adequate gastroduodenal stress prophylaxis?","volume":"14","author":"Valentine","year":"1986","journal-title":"Crit Care Med"},{"key":"2026070711354775700_bibr18-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/ajg.2013.108","article-title":"Risk of gastrointestinal bleeding in patients undergoing total hip or knee replacement compared with matched controls: a nationwide cohort study","volume":"108","author":"Lalmohamed","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"2026070711354775700_bibr19-2058-5241.6.200053","first-page":"1046","article-title":"Venous thromboembolism in very elderly patients: findings from a prospective registry (RIETE)","volume":"91","author":"L\u00f3pez-Jim\u00e9nez","year":"2006","journal-title":"Haematologica"},{"key":"2026070711354775700_bibr20-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/apt.13265","article-title":"Occult vs. overt upper gastrointestinal bleeding: inverse relationship and the use of mucosal damaging and protective drugs","volume":"42","author":"Taha","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"2026070711354775700_bibr21-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00198-017-3910-x","article-title":"Use of proton pump inhibitors and mortality after hip fracture in a nationwide study","volume":"28","author":"Brozek","year":"2017","journal-title":"Osteoporos Int"},{"key":"2026070711354775700_bibr22-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0149-2918(04)90019-7","article-title":"Stress-related mucosal disease: risk factors and prophylactic therapy","volume":"26","author":"Spirt","year":"2004","journal-title":"Clin Ther"},{"key":"2026070711354775700_bibr23-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00198-018-4788-y","article-title":"Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies","volume":"30","author":"Poly","year":"2019","journal-title":"Osteoporos Int"},{"key":"2026070711354775700_bibr24-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/MEG.0000000000000634","article-title":"Noncompliance with guidelines on proton pump inhibitor prescription as gastroprotection in hospitalized surgical patients who are prescribed NSAIDs","volume":"28","author":"van den Bemt","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2026070711354775700_bibr25-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bonr.2019.100204","article-title":"Higher dose but not low dose proton pump inhibitors are associated with increased risk of subsequent hip fractures after first hip fracture: a nationwide observational cohort study","volume":"10","author":"Brozek","year":"2019","journal-title":"Bone Reports"},{"key":"2026070711354775700_bibr26-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/BOR.0000000000000291","article-title":"Proton pump inhibitors and osteoporosis","volume":"28","author":"Andersen","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"2026070711354775700_bibr27-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cgh.2012.11.031","article-title":"Reported side effects and complications of long-term proton pump inhibitor use: dissecting the evidence","volume":"11","author":"Johnson","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026070711354775700_bibr28-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/apt.14589","article-title":"Proton pump inhibitor use and risk of hip fractures among community-dwelling persons with Alzheimer\u2019s disease: a nested case-control study","volume":"47","author":"Torvinen-Kiiskinen","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"2026070711354775700_bibr29-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jhin.2012.11.009","article-title":"Incidence and risk factors for hospital-acquired Clostridium difficile infection among inpatients in an orthopaedic tertiary care hospital","volume":"83","author":"Campbell","year":"2013","journal-title":"J Hosp Infect"},{"key":"2026070711354775700_bibr30-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-2036.2006.03015.x","article-title":"Proton pump inhibitor therapy is a risk factor for Clostridium difficile-associated diarrhoea","volume":"24","author":"Yearsley","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"2026070711354775700_bibr31-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cgh.2011.09.030","article-title":"Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analysis","volume":"10","author":"Deshpande","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026070711354775700_bibr32-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7861\/clinmedicine.18-3-237","article-title":"Clostridium difficile infection and antibiotic-associated diarrhoea","volume":"18","author":"Mullish","year":"2018","journal-title":"Clin Med (Lond)"},{"key":"2026070711354775700_bibr33-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"e15004","DOI":"10.1097\/MD.0000000000015004","article-title":"Clostridium difficile-associated diarrhea following the therapy with antibiotic and proton pump inhibitors in a77-year-old man with several comorbidities","volume":"98","author":"Lv","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"2026070711354775700_bibr34-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1001\/jama.292.16.1955","article-title":"Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs","volume":"292","author":"Laheij","year":"2004","journal-title":"JAMA"},{"key":"2026070711354775700_bibr35-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"214","DOI":"10.14797\/mdcj-15-3-214","article-title":"Cardiovascular risk of proton pump inhibitors","volume":"15","author":"Ariel","year":"2019","journal-title":"Methodist DeBakey Cardiovasc J"},{"key":"2026070711354775700_bibr36-2058-5241.6.200053","doi-asserted-by":"crossref","first-page":"e84890","DOI":"10.1371\/journal.pone.0084890","article-title":"Proton pump inhibitors and the risk of adverse cardiac events","volume":"8","author":"Juurlink","year":"2013","journal-title":"PLoS One"}],"container-title":["EFORT Open Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/pdf\/10.1302\/2058-5241.6.200053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/online.boneandjoint.org.uk\/doi\/full-xml\/10.1302\/2058-5241.6.200053","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/eor\/article-pdf\/6\/8\/686\/18372\/2058-5241.6.200053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/eor\/article-pdf\/6\/8\/686\/18372\/2058-5241.6.200053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:21:26Z","timestamp":1783441286000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/eor\/article\/6\/8\/686\/2385\/Should-we-routinely-prescribe-proton-pump"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":36,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,10]]},"published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1302\/2058-5241.6.200053","relation":{},"ISSN":["2058-5241"],"issn-type":[{"value":"2058-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,1]]}}}