{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:11:31Z","timestamp":1793171491106,"version":"4.5.0"},"reference-count":33,"publisher":"Bioscientifica","issue":"7","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":1688,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Total knee arthroplasty (TKA) is an effective procedure to treat many patients with end-stage knee arthropathy. However, the extension of TKA for patients with Charcot neuroarthropathy (CNA) is controversial, with relatively limited evidence defining optimal reconstruction techniques. This systematic review of relevant studies that were published from January 2000 to June 2020 aimed to define survivorship, complications, reoperation, and component revision rates of contemporary TKA performed for CNA. We identified 127 TKA performed for CNA in five studies that comprised \u2265 7 knees with \u2265 5 years of follow-up. Overall implant survivorship was 85.4%. The overall complication rate was 26.4%, with the most common complications including instability (24.0%), periprosthetic fracture (17.4%), infection (13.0%), ligament injury (10.9%) and aseptic loosening (10.9%). The aetiology of CNA and prosthesis type had no influence on clinical outcomes, whereas the effect of staging of disease and ataxia status was still inconclusive. Understanding the potential determinants, survivorship and risk of complications related to TKA performed in CNA may help surgeons to deal with patient expectations.<\/jats:p>\n                  <jats:p>Cite this article: EFORT Open Rev 2021;6:556-564. DOI: 10.1302\/2058-5241.6.200103<\/jats:p>","DOI":"10.1302\/2058-5241.6.200103","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T08:48:04Z","timestamp":1625734084000},"page":"556-564","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":6,"title":["Mid- to long-term outcomes of contemporary total knee arthroplasty in Charcot neuroarthropathy: a systematic review and meta-analysis"],"prefix":"10.1530","volume":"6","author":[{"given":"Piti","family":"Rattanaprichavej","sequence":"first","affiliation":[{"name":"1Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patapong","family":"Towiwat","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artit","family":"Laoruengthana","sequence":"additional","affiliation":[{"name":"1Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyameth","family":"Dilokthornsakul","sequence":"additional","affiliation":[{"name":"3Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand"},{"name":"4Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathorn","family":"Chaiyakunapruk","sequence":"additional","affiliation":[{"name":"5Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA"},{"name":"6School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"2026070711351204700_bibr1-2058-5241.6.200103","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1016\/j.arth.2016.05.062","article-title":"The fate of allogeneic femoral head bone grafts using varus-valgus constrained total knee arthroplasty in neuropathic joints","volume":"31","author":"Chun","year":"2016","journal-title":"J Arthroplasty"},{"key":"2026070711351204700_bibr2-2058-5241.6.200103","first-page":"e17","article-title":"Arthroplasty of a Charcot knee","volume":"2","author":"Babazadeh","year":"2010","journal-title":"Orthop Rev (Pavia)"},{"key":"2026070711351204700_bibr3-2058-5241.6.200103","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.arth.2018.04.003","article-title":"Primary total knee arthroplasty in patients with neuropathic (Charcot) arthropathy: contemporary 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