{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:20:59Z","timestamp":1792693259203,"version":"4.5.0"},"reference-count":71,"publisher":"Royal College of Surgeons of England","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p> In recent years, considerable progress has been made in the treatment of children with hepatoblastoma largely due to effective pre-operative chemotherapy. Total hepatectomy and liver transplantation has emerged as an effective treatment for the small proportion of children with unresectable hepatoblastoma limited to the liver. A 5-year survival of 70% can be achieved in such cases. In contrast, the results of liver transplantation in children with hepatocellular cancer remain poor because these tumours are usually advanced with evidence of major vascular invasion and\/or extrahepatic spread at the time of presentation. An exception is those children in whom the hepatocellular carcinoma is detected during surveillance of chronic liver disease \u2013 they typically have smaller tumours and frequently have a good prognosis after liver transplantation. The role of liver transplantation in children with other primary hepatic malignancies remains uncertain because experience is very limited. Liver transplantation is rarely needed in the management of children with benign liver tumours but, if other treatments have failed, it can be a life-saving intervention. <\/jats:p>","DOI":"10.1308\/003588407x155527","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T23:29:19Z","timestamp":1169594959000},"page":"12-21","source":"Crossref","is-referenced-by-count":45,"title":["The Role of Liver Transplantation in the Management of Paediatric Liver Tumours"],"prefix":"10.1308","volume":"89","author":[{"given":"Mark D","family":"Stringer","sequence":"first","affiliation":[{"name":"Children's Liver & GI Unit, St James's University Hospital Leeds, 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