{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:01:46Z","timestamp":1791856906893,"version":"4.3.4"},"reference-count":18,"publisher":"Royal College of Surgeons of England","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p> An increasing number of living-unrelated, kidney donor transplants are being performed in our unit. We present a comparison of living-unrelated (LURD) and living-related donor (LRD) renal transplant outcomes and analyse influencing factors. <\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p> We retrospectively analysed the outcome of all living-donor renal transplants performed at our centre from 1993 to 2004. The parameters studied included patient and graft survival, functioning status of grafts (determined by estimated GFR) at last follow-up and any rejection episodes. Multivariate analysis was performed for recipient and donor age, ethnicity, HLA matching and re-transplants. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> A total of 322 live donor kidney transplants (LRD, n = 261; LURD, n = 61) were carried out over this period. Mean recipient age was 28 \u00b1 16 years in the LRD group and 48 \u00b1 12 years in LURD, while mean age of the donors was 43 \u00b1 11 years and 48 \u00b1 10 years, respectively. Caucasians constituted 80% of all the living donors. Amongst LRD, parents were the commonest (58%) donors followed by siblings (35%). In LURD, 80% were spouses. A total of 33 grafts failed, 30 in LRD (11%) and 3 in LURD (5%). Thirteen patients died, 11 (4.2%) in LRD (7 with functioning graft) and 2 (3.3%) in LURD (1 with functioning graft). Acute rejections occurred in 41% recipients in LRD and 35% in LURD (P = 0.37). Estimated GFR was lower in LURD than in LRD (49 \u00b1 14 versus 59 \u00b1 29 ml\/min\/1.73 m<jats:sup>2<\/jats:sup>; P = 0.032). One- and 3-year patient survival for LRD and LURD was 98.7% and 96.3% and 97.7% and 95%, respectively (P = 0.75). One- and 3-year graft survival was equivalent at 94.8% and 92.3% for LRD, and 98.4% and 93.7% for LURD, respectively (P = 0.18). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p> Outcome of LRD and LURD is comparable in terms of patient and graft survival, acute rejection rate and estimated GFR despite differences in demographics, HLA matching and re-transplants of recipients. <\/jats:p><\/jats:sec>","DOI":"10.1308\/003588408x261636","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T01:25:58Z","timestamp":1208481958000},"page":"247-250","source":"Crossref","is-referenced-by-count":26,"title":["Living-Unrelated Donor Renal Transplantation: An Alternative to Living-Related Donor Transplantation?"],"prefix":"10.1308","volume":"90","author":[{"given":"Nadeem","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Transplantation, Guy's and St Thomas' Hospitals & GKT School of Medicine London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Guy's and St Thomas' Hospitals & GKT School of Medicine London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Shamim","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Guy's and St Thomas' Hospitals & GKT School of Medicine London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Calder","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Guy's and St Thomas' Hospitals & GKT School of Medicine London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizam","family":"Mamode","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Guy's and St Thomas' Hospitals & GKT School of Medicine London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Guy's and St Thomas' Hospitals & GKT School of Medicine London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Koffman","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Guy's and St Thomas' Hospitals & GKT School of Medicine London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"171","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200108000-00004"},{"key":"b2","first-page":"1","author":"Cecka JM","year":"2003","journal-title":"Clin 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