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Establishment of the aetiology and pathogenesis of periodontitis, understanding of the unique genetic and environmental susceptibility profile of affected subjects, and recognition of the systemic implications of periodontal infections are the key research findings. The use of randomised, controlled, clinical trials has allowed the development of evidence-based periodontology. Adjunctive antimicrobial therapy, regenerative periodontal surgery, periodontal plastic surgery, bone regeneration surgery in the light of implant treatment, and advanced soft tissue management at implant sites have radically changed practice. <\/jats:p>","DOI":"10.1308\/135576100322578906","type":"journal-article","created":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T22:10:18Z","timestamp":1071785418000},"page":"149-152","source":"Crossref","is-referenced-by-count":3,"title":["Advances in Periodontology"],"prefix":"10.1177","volume":"os7","author":[{"given":"Maurizio S","family":"Tonetti","sequence":"first","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,10,1]]},"reference":[{"key":"bibr1-135576100322578906","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.322"},{"key":"bibr2-135576100322578906","first-page":"54","author":"Tonetti M.","year":"1993","journal-title":"First European Workshop on Periodontology"},{"key":"bibr3-135576100322578906","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.5s.474"},{"key":"bibr4-135576100322578906","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"bibr5-135576100322578906","first-page":"431","volume":"13","author":"L\u00f6e H","year":"1986","journal-title":"Rapid, moderate and no loss of attachment in Shri-Lankan laborers 14 to 46 year of age. 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