{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:13:21Z","timestamp":1789834401672,"version":"4.0.1"},"reference-count":31,"publisher":"Royal College of Surgeons of England","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Perineal defects are commonly encountered in an oncological setting although they may also present as a result of trauma and infection (eg following Fournier\u2019s gangrene). Reconstruction of these poses functional as well as aesthetic challenges. Skin coverage and tissue volume may both be required in addition to anogenital preservation or reconstruction. General prerequisites of an adequate reconstruction of perineal defects include provision of skin cover, well vascularised tissue to fill the dead space (reducing fluid collection and infection), vulvovaginal reconstruction and no faecal or urinary contamination. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> A literature search was performed using PubMed and MEDLINE<jats:sup>\u00ae<\/jats:sup>. The search terms included \u2018perineal defects\u2019, \u2018perineal reconstruction\u2019, \u2018perforator flaps for perineum\u2019, \u2018vulval flaps\u2019, \u2018secondary healing of wound\u2019 and \u2018vacuum assisted closure\u2019. Backward chaining of reference lists from retrieved papers was also used to expand the search. <\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p> Modern developments have led to an increased expectation in improved quality of life as the main goal of reconstruction, therefore necessitating surgery with less morbidity and early return to normal activity. Progress in microsurgical procedures has been the main recent advance in perineal reconstruction and, in future, refinements in perforator flap design and tissue engineering techniques will lead to even better reconstructions. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2013.95.8.539","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T12:22:09Z","timestamp":1437999729000},"page":"539-544","source":"Crossref","is-referenced-by-count":48,"title":["Reconstruction of perineal defects"],"prefix":"10.1308","volume":"95","author":[{"given":"M","family":"Mughal","sequence":"first","affiliation":[{"name":"Royal Free London NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RJ","family":"Baker","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust, 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