{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:04:53Z","timestamp":1773353093421,"version":"3.50.1"},"reference-count":8,"publisher":"Royal College of Surgeons of England","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Brunner\u2019s glands are submucosal glands found in the duodenum. Proliferation of these glands can lead to the formation of Brunner\u2019s gland hamartomas (BGHs), which are uncommon, asymptomatic and usually found incidentally. They are predominantly benign lesions, but instances of malignant transformation have been reported. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case History<\/jats:title><jats:p> We describe a rare case in which a periampullary lesion was causing biliary obstruction on a background of weight loss, and was associated with dilatation of the common bile duct and pancreatic duct on computed tomography and magnetic resonance imaging. Further investigation with endoscopic ultrasound and biopsy did not provide a definitive diagnosis. Given the symptoms and findings upon investigations, we proceeded to pylorus-preserving pancreatoduodenectomy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> This was a rare case in which BGH gave rise to biliary obstruction against a background of weight loss. Due to a high index of suspicion (weight loss and evidence of dilatation of the common bile duct and pancreatic duct), this procedure was justified because the consequences of a missed periampullary cancer far outweighed surgical risks. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2016.0131","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T22:28:52Z","timestamp":1460154532000},"page":"e92-e93","source":"Crossref","is-referenced-by-count":5,"title":["Brunner\u2019s gland hamartoma: a cause of the double-duct sign"],"prefix":"10.1308","volume":"98","author":[{"given":"M","family":"Kostalas","sequence":"first","affiliation":[{"name":"Royal Surrey County Hospital, Guildford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jackson","sequence":"additional","affiliation":[{"name":"Royal Surrey County Hospital, Guildford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Karanjia","sequence":"additional","affiliation":[{"name":"Royal Surrey County Hospital, Guildford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"171","reference":[{"key":"bib1","first-page":"81","volume":"49","author":"Chattopadhyay P","year":"2008","journal-title":"Singapore Med J"},{"key":"bib2","first-page":"295","volume-title":"Surgical pathology of the GI tract, liver, biliary tract and pancreas","author":"Yantis RK","year":"2004"},{"key":"bib3","first-page":"276","volume":"77","author":"Peison B","year":"1982","journal-title":"Am J Gastroenterol"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.79.933.416"},{"key":"bib5","first-page":"290","volume":"90","author":"Levine JA","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"bib6","first-page":"253","volume":"60","author":"Jansen JM","year":"2002","journal-title":"Neth J Med"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2441041978"},{"key":"bib8","first-page":"348","volume":"6","author":"Iusco D","year":"2005","journal-title":"J Pancreas (Online)"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2016.0131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:17:47Z","timestamp":1684145867000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2016.0131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1308\/rcsann.2016.0131"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2016.0131","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}