{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:28:23Z","timestamp":1790162903467,"version":"4.1.0"},"reference-count":25,"publisher":"Royal College of Surgeons of England","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p> The 2012 British Association of Endocrine and Thyroid Surgeons audit report showed that only 86 of 1359 patients who underwent adrenalectomy had a bilateral operation; thus the experience with this procedure remains limited. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> Retrospective review of patients undergoing bilateral adrenalectomy in a tertiary referral centre. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Between November 2005 and January 2016, bilateral adrenalectomy was performed in 23 patients (6 male, 17 female, age 43 \u00b1 4 years) diagnosed with Cushing\u2019s disease (n = 13), hereditary phaeochromocytomas (n = 6), adrenocortical cancer (n = 2), colorectal metastatic disease (n = 1) and adrenocortical adenomas (n = 1). A laparoscopic transperitoneal approach was used in 17 patients, with one conversion to open. Three patients had open adrenalectomies for adrenocortical cancer and for simultaneous phaeochromocytomas and pancreatic neuroendocrine tumours in a patient with Von Hippel-Lindau syndrome. Three patients with Cushing\u2019s had a bilateral retroperitoneoscopic operation. The mean operating time was 195 \u00b1 16 minutes for laparoscopic operations (n = 16), 243 \u00b1 44 minutes for open adrenalectomies (n = 4) and 151 \u00b1 12 minutes for retroperitoneal operations. It was significantly shorter for Cushing\u2019s disease than for phaeochromocytomas (162 \u00b1 8 vs. 257 \u00b1 39 minutes, P &lt; 0.01). Median length of hospital stay was 5 days. Postoperative complications (Clavien-Dindo classification) included one chest infection (level 2), one postoperative haemorrhage and two chest drains for pneumothorax (level 3), two postoperative cardiac arrests (level 4) and one late cancer death from complications related to uncontrolled hypercortisolism (level 5). <\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p> Synchronous bilateral adrenalectomy remains an infrequent operation. The laparoscopic approach is feasible in the majority of patients. It is likely that the retroperitoneoscopic adrenalectomy will become the standard approach for bilateral operations. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2016.0266","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T15:38:03Z","timestamp":1471966683000},"page":"119-122","source":"Crossref","is-referenced-by-count":19,"title":["Bilateral adrenalectomy: a review of 10 years\u2019 experience"],"prefix":"10.1308","volume":"99","author":[{"given":"D","family":"Maccora","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GV","family":"Walls","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GP","family":"Sadler","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"171","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2009.191"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3750-2"},{"key":"bib3","volume-title":"Fourth National Audit Report 2012"},{"key":"bib4","first-page":"1003","volume":"327","author":"Gagner M","year":"1992","journal-title":"N Engl J Med"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900117"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8921"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.3171\/2014.10.FOCUS14684"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0265"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02846.x"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0549"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.159"},{"key":"bib13","first-page":"1,088","volume":"116","author":"O Riordain DS","year":"1994","journal-title":"Surgery"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2014.03.007"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-007-9478-3"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03082.x"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.039"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.025"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8921"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.05.042"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1294-1"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2326-9"},{"key":"bib23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/000313481107700414","volume":"77","author":"Ramacciato G","year":"2011","journal-title":"Am Surg"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.07.010"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1470"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2016.0266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:50:07Z","timestamp":1684147807000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2016.0266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1308\/rcsann.2016.0266"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2016.0266","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}