{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:00:48Z","timestamp":1773471648998,"version":"3.50.1"},"reference-count":19,"publisher":"Royal College of Surgeons of England","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2017,5]]},"abstract":"INTRODUCTION<\/jats:title> Parathyroidectomy is the definitive treatment for primary hyperparathyroidism but the intraoperative identification of adenomas is challenging. The aim of this study was to evaluate the utility of a radionuclide probe (RNP) in addition to intraoperative parathyroid hormone ( IOPTH) measurement as an intraoperative diagnostic adjunct in patients undergoing parathyroidectomy for primary hyperparathyroidism. <\/jats:p><\/jats:sec>METHODS<\/jats:title> This was a retrospective cohort study of patients treated between 2004 and 2015 in a university affiliated teaching hospital. Patients were grouped into those with RNP use (RNP+) and those without (RNP-). The primary outcome measure was rate of operative failure, which included false positives. The diagnostic sensitivity and positive predictive value of both RNP and IOPTH were also evaluated. <\/jats:p><\/jats:sec>RESULTS<\/jats:title> A total of 298 patients were included in the study, 127 (42.6%) being in the RNP+ group and 171 (57.4%) in the RNP- group. The false positive rate for the RNP+ patients was 1.6% compared with 9.4% for RNP- patients (p=0.006, hazard ratio [HR]: 6.45). The rates of operative failure were 6.3% and 11.7% respectively (p=0.159, HR: 1.97). RNP use had a sensitivity of 92.0% and a positive predictive value of 98.3% compared with 78.6% and 95.2% respectively for IOPTH monitoring. <\/jats:p><\/jats:sec>CONCLUSIONS<\/jats:title> RNP use is associated with fewer false positives and reduced operative failure than IOPTH measurement. It also has a higher sensitivity and positive predictive value. RNP use is recommended in centres that have the required facilities. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2017.0016","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T11:23:22Z","timestamp":1493724202000},"page":"369-372","source":"Crossref","is-referenced-by-count":15,"title":["The utility of the radionuclide probe in parathyroidectomy for primary hyperparathyroidism"],"prefix":"10.1308","volume":"99","author":[{"given":"MS","family":"Lim","sequence":"first","affiliation":[{"name":"Cork University Hospital, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Jinih","sequence":"additional","affiliation":[{"name":"Cork University Hospital, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CH","family":"Ngai","sequence":"additional","affiliation":[{"name":"Cork University Hospital, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NM","family":"Foley","sequence":"additional","affiliation":[{"name":"Cork University Hospital, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HP","family":"Redmond","sequence":"additional","affiliation":[{"name":"Cork University Hospital, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"171","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1080\/02813430600784443"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.06.051"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200205000-00008"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000207"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.10.021"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90135-Z"},{"key":"bib7","first-page":"1,111","volume":"112","author":"Wei JP","year":"1992","journal-title":"Surgery"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-13-36"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6620-1"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2014.29.4.464"},{"key":"bib11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/SLA.0b013e3181859f71","volume":"248","author":"Siperstein A","year":"2008","journal-title":"Ann Surg"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181d3d264"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2006.01.006"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101578"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.05.059"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000062"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.104"},{"key":"bib18","first-page":"1,801","volume":"33","author":"Taillefer R","year":"1992","journal-title":"J Nucl Med"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318208fed9"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2017.0016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:51:13Z","timestamp":1684147873000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2017.0016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1308\/rcsann.2017.0016"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2017.0016","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}