{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:24:15Z","timestamp":1777019055191,"version":"3.51.4"},"reference-count":17,"publisher":"Royal College of Surgeons of England","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism is dependent upon accurate prediction of single-gland disease on the basis of preoperative imaging and biochemistry. The aims of this study were to validate currently available predictive models of single-gland disease in two UK cohorts and to determine if these models can facilitate MIP. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> This is a retrospectively cohort study of 624 patients who underwent parathyroidectomy for primary hyperparathyroidism in two centres between July 2008 and December 2013. Two recognised models: CaPTHUS (preoperative calcium, parathyroid hormone, ultrasound, sestamibi, concordance imaging) and Wisconsin Index (preoperative calcium, parathyroid hormone) were validated for their ability to predict single-gland disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The rates of single- and multi-gland disease were 491 (79.6%) and 126 (20.2%), respectively. Cure rates in centres 1 and 2 were 93.2% and 93.8%, respectively (P = 0.789). The positive predictive value (PPV) of CaPTHUS score . 3 in predicting single-gland disease was 84.6%, compared with 100% in the original report. CaPTHUS . 4 and 5 had a PPV of 85.1 and 87.1, respectively. There were no differences in Wisconsin Index (WIN) between patients with single- and multi-gland (P = 0.573). A WIN greater than 1600 and weight of excised gland greater than 1 g had a positive predictive value of 86.7% for single-gland disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The use of CaPTHUS and WIN indices without intraoperative adjuncts (such as IOPTH) had the potential to result in failure to cure in up to 15% (CaPTHUS) and 13% (WIN) of patients treated by MIP targeting a single enlarged gland. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2017.0112","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T15:25:45Z","timestamp":1505489145000},"page":"140-145","source":"Crossref","is-referenced-by-count":28,"title":["Current predictive models do not accurately differentiate between single and multi gland disease in primary hyperparathyroidism: a retrospective cohort study of two endocrine surgery units"],"prefix":"10.1308","volume":"100","author":[{"given":"O","family":"Edafe","sequence":"first","affiliation":[{"name":"Department of Oncology and Metabolism, University of Sheffield and Sheffield Teaching Hospitals Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EE","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism, University of Sheffield and Sheffield Teaching Hospitals Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CS","family":"Ubhi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism, University of Sheffield and Sheffield Teaching Hospitals Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SP","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism, University of Sheffield and Sheffield Teaching Hospitals Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"171","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03520.x"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1013"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4080-0"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1377-z"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.8.777"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31825ffbe1"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2013.02.002"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2010.05488.x"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3479-3"},{"issue":"3","key":"bib11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/SLA.0b013e3181859f71","volume":"248","author":"Siperstein A","year":"2008","journal-title":"Ann Surg"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-015-1348-1"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04183.x"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5574"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-016-1426-z"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9191-9"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2327-8"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2017.0112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:38:40Z","timestamp":1684147120000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2017.0112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1308\/rcsann.2017.0112"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2017.0112","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}