{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:59:58Z","timestamp":1792479598846,"version":"4.5.0"},"reference-count":41,"publisher":"Royal College of Surgeons of England","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Solitary extramedullary plasmacytoma are rare, solid-mass tumours which appear immunophenotypically similar to multiple myeloma. The diagnosis and management of gastrointestinal plasmacytoma is complex and requires multidisciplinary input. This study presents a narrative review of intra-abdominal extramedullary plasmacytoma, illustrated with two case studies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> The PubMed database was searched without date restrictions for reports of intra-abdominal extramedullary plasmacytoma to synthesise a narrative review. Electronic records were reviewed at a high-volume, quaternary soft-tissue sarcoma centre to identify patients with histopathologically confirmed extramedullary plasmacytoma affecting the gastrointestinal tract. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Gastrointestinal extramedullary plasmacytomas can present with mass effect or organ-specific dysfunction. Techniques for tissue diagnosis of extramedullary plasmacytoma vary dependent on location, with a formal diagnosis often being made from a resected specimen. Management can include surgery, radiotherapy, systemic chemotherapy or a combination. No high-quality evidence base exists to guide treatment. Two case studies of operated gastrointestinal extramedullary plasmacytoma are presented at different phases of disease progression, with a resultant impact on survival. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Intra-abdominal extramedullary plasmacytoma is a rare and heterogeneous condition that lacks consensus guidelines for diagnosis and management. Collaboration between international specialist centres will create better quality evidence for treatment of this cohort. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2018.0015","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T11:36:51Z","timestamp":1524656211000},"page":"371-376","source":"Crossref","is-referenced-by-count":28,"title":["Gastrointestinal manifestations of extramedullary plasmacytoma: a narrative review and illustrative case reports"],"prefix":"10.1308","volume":"100","author":[{"given":"JC","family":"Glasbey","sequence":"first","affiliation":[{"name":"Department of Soft Tissue Sarcoma, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue Sarcoma, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LM","family":"Almond","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue Sarcoma, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Vydianath","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue Sarcoma, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gourevitch","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue Sarcoma, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SJ","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue Sarcoma, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"171","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813481334"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.165876"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3936"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2015.05.045"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.08.043"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-202563"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.005"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-210973"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2013.02.018"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rju016"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.140799"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14291"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06599.x"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2015.02.006"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13870"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00544.x"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2691"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.091918"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v6.i3.99"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.180481"},{"issue":"2","key":"bib21","first-page":"E7","volume":"6","author":"Romain PS","year":"2014","journal-title":"J Gastrointest Oncol"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.5328.5328"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1377428"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12160"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.03.005"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.9.3741"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2014.47.6.564"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.10202"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2014.63.5.316"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2016.08.041"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-5-47"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-008-0439-7"},{"issue":"4","key":"bib33","first-page":"152","volume":"6","author":"Lee S","year":"2013","journal-title":"Gastroenterol Res"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.5152\/UCD.2013.45"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.08.003"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.1.74"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2014.47.1.115"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2015.05.001"},{"issue":"7","key":"bib39","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.5858\/2004-128-e86-EEPOTA","volume":"128","author":"Rogers CG","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006092"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.1159\/000273481"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2018.0015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:38:40Z","timestamp":1684147120000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2018.0015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1308\/rcsann.2018.0015"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2018.0015","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}