{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T15:59:36Z","timestamp":1762444776598},"reference-count":28,"publisher":"Royal College of Surgeons of England","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Introduction<\/jats:title> The aim of this study was to determinate the outcome of indeterminate liver lesions on computed tomography (CT) in patients with a background history of colorectal cancer (CRC) and to identify clinicopathological variables associated with malignancy in these lesions. A secondary aim was to devise a management algorithm for such patients. <\/jats:p><\/jats:sec>Methods<\/jats:title> Patients referred to our institution with indeterminate liver lesions on CT with a background history of CRC between January 2012 and December 2014 were included in the study. Clinicopathological factors, surveillance period and histological findings were analysed. <\/jats:p><\/jats:sec>Results<\/jats:title> Fifty-six patients with indeterminate liver lesions were identified. Fifty-three (94.6%) of these required further imaging (magnetic resonance imaging [MRI; n=50] and positron emission tomography combined with CT [n=3]). For the patients who had MRI, the underlying diagnosis was benign in 19 and colorectal liver metastasis (CRLM) in 8 while 23 patients and an indeterminate lesion. In cases that remained indeterminate following MRI, liver resection was performed in 2 patients for a high suspicion of CRLM while the 21 remaining patients underwent interval surveillance (median: 9 months, range: 3\u201352 months). Of these 21 patients, 14 had benign lesions while CRLM was noted in 6 patients and an incidental hepatocellular carcinoma in a single patient. Age \u226565 years was the only statistically significant clinicopathological factor in predicting an underlying malignancy in patients with indeterminate liver lesions on CT. <\/jats:p><\/jats:sec>Conclusions<\/jats:title> Over a third of the patients diagnosed with indeterminate liver lesions on CT subsequently showed evidence of CRLM. These indeterminate lesions are more likely to be malignant in patients aged \u226565 years. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2018.0070","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T11:36:51Z","timestamp":1524656211000},"page":"382-387","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of indeterminate liver lesions on computed tomography in patients with colorectal cancer"],"prefix":"10.1308","volume":"100","author":[{"given":"E","family":"Mohamed","sequence":"first","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Adiamah","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WK","family":"Dunn","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Higashi","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IC","family":"Cameron","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Gomez","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"171","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12323"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v8.i34.1502"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-013-9569-4"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2013.04.014"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.1.r99ja0371"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200209000-00009"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1080\/13651820701216950"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.2174\/157340512800672216"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066141"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2009.00127.x"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0239-6"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-015-0590-2"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603558"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5278"},{"key":"bib18","first-page":"283","volume":"4","author":"Kanas GP","year":"2012","journal-title":"Clin Epidemiol"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6751"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9465"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.12.2386"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2003.09.012"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21569"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.063040"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e32833fa9ba"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.11.025"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7136"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2009.00081.x"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2018.0070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:38:46Z","timestamp":1684147126000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2018.0070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1308\/rcsann.2018.0070"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2018.0070","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}