{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:57:21Z","timestamp":1779335841151,"version":"3.51.4"},"reference-count":19,"publisher":"Royal College of Surgeons of England","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Recent prospective studies support the feasibility of performing sentinel lymph node biopsy following neoadjuvant chemotherapy in initially fine-needle aspiration cytology or ultrasound-guided biopsy-proven node-positive breast cancer. The main aid is to identify preoperative features that help us predict a complete axillary response to neoadjuvant chemotherapy in these patients and thus select the candidates for sentinel lymph node biopsy post-neoadjuvant chemotherapy to avoid unnecessary axillary lymphadenectomy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p> A retrospective observational study with a total of 150 patients, biopsy-proven node-positive breast cancer who underwent neoadjuvant chemotherapy followed by breast surgery and axillary lymphadenectomy were included and retrospectively analysed. A predictive model was generated by a multivariate logistic regression analysis for pathological complete response-dependent variable. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The response of the primary lesion to neoadjuvant chemotherapy according to post-treatment magnetic resonance imaging, Her2\/neu overexpression and a low estrogen receptor expression are associated with a higher rate of nodal pathologically complete response. The multivariant model generated a receiver operating characteristic curve with an area under the curve of 0.79 and a confidence interval of 0.72\u20130.87 at a 95% level of significance. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> This model could be a helpful tool for the surgeon to help in predicting which cases have a higher likelihood of achieving a pathologically complete response and therefore selecting those who may benefit from a post-neoadjuvant chemotherapy sentinel lymph node biopsy and avoid unnecessary axillary lymphadenectomy. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2018.0196","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T10:09:20Z","timestamp":1542103760000},"page":"186-192","source":"Crossref","is-referenced-by-count":12,"title":["Is it always necessary to perform an axillary lymph node dissection after neoadjuvant chemotherapy for breast cancer?"],"prefix":"10.1308","volume":"101","author":[{"given":"I","family":"Osorio-Silla","sequence":"first","affiliation":[{"name":"Department of Surgery, Hospital Universitario La Pa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"G\u00f3mez Valdazo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J I","family":"S\u00e1nchez M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"York","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario La Pa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"D\u00edaz-Almir\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario La Pa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"G\u00f3mez Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rivas Fidalgo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JM","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitario La Paz, Madrid, 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