{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:28:02Z","timestamp":1791444482392,"version":"4.3.3"},"reference-count":16,"publisher":"Royal College of Surgeons of England","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Introduction<\/jats:title> This prospective study of foam sclerotherapy for varicose veins aimed to determine the outcomes of treatment including ulcer healing and complication rates in our unit. Data were collected prospectively over a 10-year period and maintained on a database by our vascular sciences unit, which performed the planning and post-treatment venous duplex scans. Patients undergoing treatment due to venous ulceration were identified from this database. An initial cohort of patients underwent a follow-up scan and assessment at one year. <\/jats:p><\/jats:sec>Materials and methods<\/jats:title> Patients were treated with foam sclerotherapy, in multiple sessions if required, to occlude all incompetent superficial veins greater than 3 mm in size. We used 3% sodium tetradecyl sulphate as our sclerosing agent, according to our departmental protocol, followed by a period of compression therapy. Patients underwent pre- and post-treatment scans to assess venous competence, the effects of treatment and any complications that arose. <\/jats:p><\/jats:sec>Results<\/jats:title> We identified 336 patients treated for clinical, aetiological, anatomical and pathophysiological stage 5\/6 venous ulceration. At six weeks post-treatment, 21% had fully healed ulcers and a further 46.1% were clinically improving with no further venous incompetence. The remainder continued treatment. An initial cohort of 162 patients was assessed at one year and 77.1% ulcers remained healed. The remainder demonstrated some venous incompetence and ultimately 12.5% required further treatment. Our complication rates were similar to those quoted in published meta-analyses including a deep vein thrombosis rate of 1.16%. <\/jats:p><\/jats:sec>Conclusions<\/jats:title> Foam sclerotherapy remains a useful treatment option for venous ulceration with a low morbidity rate. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2018.0218","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T10:07:26Z","timestamp":1546510046000},"page":"285-289","source":"Crossref","is-referenced-by-count":10,"title":["The effects of foam sclerotherapy on ulcer healing: a single-centre prospective study"],"prefix":"10.1308","volume":"101","author":[{"given":"G","family":"Cuffolo","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Oxford University Hospitals, Oxford, UK"},{"name":"Department of General Surgery, Wexham Park Hospital, Wexham, Slough, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hardy","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Oxford University Hospitals, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Oxford University Hospitals, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LJ","family":"Hands","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Oxford University Hospitals, Oxford, UK"},{"name":"Nuffield Department of Surgery, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"171","reference":[{"key":"bib1","volume-title":"Varicose Veins: Diagnosis and Management","author":"National Institute for Health and Care Excellence","year":"2013"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1177\/0268355515589536"},{"issue":"7","key":"bib3","first-page":"CD005624","author":"Nesbitt C","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70134-2"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70330-7"},{"key":"bib6","first-page":"129","volume":"53","author":"Tessari L","year":"2000","journal-title":"Phlebologie"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.11.025"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.05.027"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.08.011"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2011.011118"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5891"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2011.011111"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2012.10.060"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801214"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16353-8"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2013.04.008"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2018.0218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:34:19Z","timestamp":1684146859000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2018.0218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1308\/rcsann.2018.0218"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2018.0218","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}