{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:14:54Z","timestamp":1780344894152,"version":"3.54.1"},"reference-count":19,"publisher":"Royal College of Surgeons of England","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Congenital mesoblastic nephroma is a rare disease. Treatment is surgical in the first instance. Chemotherapy has traditionally been thought not to have a role. Recent literature suggests a 50% mortality rate for recurrent\/metastatic disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p> This study is a retrospective case review of prospectively collected data. Demographics, histopathology, treatment, outcomes and follow up were reviewed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Nine patients, 6 male and 3 female, were included. The median age at presentation was one month (range 0\u20137 months); follow-up was for a median of 21.5 months (range 16\u201379 months). Two patients had mixed and classical subtypes and the other five had the cellular subtype. Surgery was completed by an open procedure in eight patients and laparoscopically in one. There were three recurrences; two were local and one was pulmonary. Recurrences were treated with a combination of chemotherapy, radiotherapy and surgery. One patient with recurrent disease died from acute-on-chronic respiratory failure secondary to lung irradiation but was disease free. The other eight are disease free, alive and well with no sequelae at latest follow-up. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Surgery remains the mainstay of management with chemo- and radiotherapy reserved for unresectable tumours or adjuvant management of recurrent disease. Specimen-positive margins are not an indication for instituting chemotherapy. The tyrosine kinase pathway seems to be a potential target for future chemotherapeutic agents although it is too early to assess how that will impact on the management of congenital mesoblastic nephroma. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2019.0111","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T13:22:01Z","timestamp":1568208121000},"page":"67-70","source":"Crossref","is-referenced-by-count":14,"title":["Congenital mesoblastic nephroma: a single-centre series"],"prefix":"10.1308","volume":"102","author":[{"given":"M","family":"Pachl","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery and Urology, Birmingham Children\u2019s Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GS","family":"Arul","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Urology, Birmingham Children\u2019s Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Jester","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Urology, Birmingham Children\u2019s Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Birmingham Children\u2019s Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Hobin","sequence":"additional","affiliation":[{"name":"Oncology Department, Birmingham Children\u2019s Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Morland","sequence":"additional","affiliation":[{"name":"Oncology Department, Birmingham Children\u2019s Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"171","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21836"},{"key":"bib2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1542\/peds.40.2.272","volume":"40","author":"Bolande RP","year":"1967","journal-title":"Paediatrics"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(01)00528-3"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4149-5"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1985.tb02860.x"},{"key":"bib6","first-page":"98","volume":"110","author":"Beckwith B","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1276"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22871"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200309000-00001"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26437"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880006"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.3109\/15513819309048202"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22486"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.127"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2015.11.007"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2938"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1002\/path.4677"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-19"},{"key":"bib19","doi-asserted-by":"crossref","first-page":"e000023","DOI":"10.1136\/esmoopen-2015-000023","volume":"1","author":"Alessio Amatu","year":"2016","journal-title":"ESMO Open"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2019.0111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:45:21Z","timestamp":1684147521000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2019.0111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1308\/rcsann.2019.0111"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2019.0111","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}