{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:17:59Z","timestamp":1788866279031,"version":"build-2803163510"},"reference-count":5,"publisher":"Royal College of Surgeons of England","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p> Calcitonin-negative medullary thyroid carcinoma is a rare, poorly understood primary neuroendocrine carcinoma of the thyroid characterised by classic medullary thyroid carcinoma morphology without raised serum calcitonin. A 24-year-old woman presented with a slow-growing, right-sided neck swelling. She underwent an ultrasound scan, cytopathological and histopathological examination, and tests for alternative diagnoses. The ultrasound showed a heterogeneous, hyperechoic nodule in the right thyroid lobe. Serum calcitonin was normal. Cytopathology and histopathology showed typical medullary thyroid carcinoma morphology but without calcitonin upon immunostaining and mRNA in situ hybridisation. A \u2018triple-negative\u2019 calcitonin-negative medullary thyroid carcinoma was diagnosed. A completion thyroidectomy with bilateral central lymph node dissection was performed. The patient remains well three-years post-surgery. When cytopathology suggests a medullary thyroid carcinoma, serum calcitonin, pro-calcitonin, carcinoembryonic antigen and calcitonin-gene-related peptide should be measured to identify cases of calcitonin-negative medullary thyroid carcinoma. They should also be measured post-treatment for monitoring purposes. This will aid future calcitonin-negative medullary thyroid carcinoma diagnoses and will inform prognostic stratification and influence treatment decisions. <\/jats:p>","DOI":"10.1308\/rcsann.2019.0153","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T13:37:10Z","timestamp":1576503430000},"page":"e63-e66","source":"Crossref","is-referenced-by-count":11,"title":["Calcitonin-negative medullary thyroid carcinoma: the \u2018triple-negative\u2019 phenotype"],"prefix":"10.1308","volume":"102","author":[{"given":"DC","family":"Murphy","sequence":"first","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SJ","family":"Johnson","sequence":"additional","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Aspinall","sequence":"additional","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"171","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0335"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2007-0239"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0058"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.4.587"},{"key":"bib5","author":"Stephenson TJ","year":"2014","journal-title":"Standards and Datasets for Reporting Cancers. Dataset for Thyroid Cancer Histopathology Reports"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2019.0153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:21:40Z","timestamp":1684146100000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2019.0153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1308\/rcsann.2019.0153"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2019.0153","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}