{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:43:16Z","timestamp":1763116996146},"reference-count":21,"publisher":"Royal College of Surgeons of England","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p> Medullary thyroid carcinoma (MTC) is relatively rare, and has the main feature of calcitonin (Ct) secretion. However, a few cases of MTC with negative serum calcitonin have been reported in the literature, so the diagnosis and follow up of Ct-negative MTCs are still a challenge. Here we present three cases of Ct-negative MTCs, illustrating the rarity of the disease and challenges in managing it, together with a review of the literature of 39 MTCs with negative serum Ct. <\/jats:p>","DOI":"10.1308\/rcsann.2020.7118","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:18:36Z","timestamp":1684145916000},"page":"221-230","source":"Crossref","is-referenced-by-count":4,"title":["Clinical challenges with calcitonin-negative medullary thyroid carcinoma: three case reports and a review of the literature"],"prefix":"10.1308","volume":"104","author":[{"given":"Z","family":"Jingzhu","sequence":"first","affiliation":[{"name":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, P. R. China"},{"name":"Tianjin\u2019s Clinical Research Centre for Cancer, P. R. 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