{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:32:23Z","timestamp":1773055943293,"version":"3.50.1"},"reference-count":32,"publisher":"Royal College of Surgeons of England","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Vitamin D deficiency co-exists with and can confuse the diagnosis of primary hyperparathyroidism (PHPT). Vitamin D replete (VDR) status may prevent significant postparathyroidectomy hypocalcaemia; however, reports from previous studies are conflicting. This study aimed to assess differences in early and\/or late postoperative hypocalcaemia and length of stay (LOS) postparathyroidectomy between VDR and vitamin D non-replete (VDNR) PHPT patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> This was a retrospective cohort study of a prospectively maintained single surgeon operative database. All records of patients who underwent parathyroidectomy over a four-year period (July 2014 to December 2018) were extracted. Data were collected on vitamin D and corrected calcium levels pre- and postoperatively as well as postoperative complications and LOS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> On presentation, there were 91 (47.9%) VDR and 99 (52.1%) VDNR patients. Following vitamin D therapy there were 148 (77.9%) VDR and 42 (22.1%) VDNR. The multivariate analysis showed that vitamin D status was the only significant factor impacting on the hypocalcaemia symptoms (OR 4.9, 95% CI 1.8\u201313.7, p\u2009=\u20090.002) and the most significant factor for the calcium supplementation (OR 6.5, 95% CI 2.1\u201319.4, p\u2009=\u20090.001). Bilateral neck exploration was associated with increased likelihood of transient hypocalcaemia (p\u2009=\u20090.007) but no other post-op complication. Median LOS was significantly shorter for VDR (1 day) versus VDNR (1.5 days) patients (p\u2009=\u20090.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> There is a statistically significant increased likelihood of postoperative hypocalcaemia symptoms, requirement for calcium supplements and increased LOS in VDNR patients. This study suggests optimising preoperative vitamin D status improves patient experience and could reduce healthcare costs. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2021.0078","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:14:57Z","timestamp":1684145697000},"page":"41-47","source":"Crossref","is-referenced-by-count":10,"title":["Vitamin D repletion in primary hyperparathyroid patients undergoing parathyroidectomy leads to reduced symptomatic hypocalcaemia and reduced length of stay: a retrospective cohort study"],"prefix":"10.1308","volume":"104","author":[{"given":"R","family":"Acharya","sequence":"first","affiliation":[{"name":"Salford Royal NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kopczynska","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Goodmaker","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Doran","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"171","reference":[{"key":"C1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1215"},{"key":"C2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0430"},{"key":"C3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01225"},{"key":"C4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3318"},{"key":"C5","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2016.41"},{"key":"C6","volume-title":"Endotext","author":"Bikle D","year":"2000"},{"key":"C7","author":"Griffin G","year":"2020","journal-title":"Clin Med (Lond)"},{"key":"C8","first-page":"1","volume":"921","year":"2003","journal-title":"World Health Organ Tech Rep Ser"},{"key":"C9","unstructured":"National Institute for Health & Care Excellence. Vitamin D: Increasing supplement use in at-risk group. https:\/\/wwwniceorguk\/guidance\/ph56."},{"key":"C10","unstructured":"Scientific Advisory Committee on Nutrition. Vitamin D and health. https:\/\/wwwgovuk\/government\/groups\/scientific-advisory-committee-on-nutrition."},{"key":"C11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1414"},{"key":"C12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02371.x"},{"key":"C13","doi-asserted-by":"publisher","DOI":"10.1177\/2042018810389646"},{"key":"C14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/B978-0-12-397166-1.00043-6","volume-title":"The Parathyroids","author":"Heaney RP","year":"2015","edition":"3"},{"key":"C15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1772"},{"key":"C16","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.09.026"},{"key":"C17","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0528"},{"key":"C18","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0377-8"},{"key":"C19","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.417"},{"key":"C20","first-page":"N75","volume":"17","author":"Rao DS","year":"2002","journal-title":"J Bone Miner Res"},{"key":"C21","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00294-6"},{"key":"C22","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0239-y"},{"key":"C23","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346273"},{"key":"C24","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.110"},{"key":"C25","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.08.026"},{"key":"C26","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3978"},{"key":"C27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1413"},{"key":"C28","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.09.018"},{"key":"C29","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0416"},{"key":"C30","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01775.x"},{"key":"C31","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12518"},{"key":"C32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.04.022"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2021.0078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:16:24Z","timestamp":1684145784000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2021.0078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1308\/rcsann.2021.0078"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2021.0078","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}