{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:27:17Z","timestamp":1761294437467},"reference-count":13,"publisher":"Royal College of Surgeons of England","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Hypoparathyroidism is a recognised complication following laryngectomy; it is associated with significant short-and long-term morbidity. This study aimed to further characterise this condition, identify risk factors and describe preventative and management strategies in a large cohort. <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p> This was a retrospective study at a tertiary referral centre for head and neck cancers. All consecutive patients who had total laryngectomy over an eight-year period were included. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> A total of 140 patients were included. Rates of transient and long-term hypoparathyroidism were 14.3% and 10.1%, respectively. The following factors were significantly associated with transient post-surgical hypocalcaemia or hypoparathyroidism: total thyroidectomy (relative risk, RR, 4.33; 95% confidence interval, CI, 1.86\u201310.10), oesophagectomy (RR 6.05; 95% CI 2.92\u201312.53) and female sex (RR 3.23; 95% CI 1.45\u20137.19). In addition, total thyroidectomy (RR 5.89; 95% CI 1.94\u201317.86), central neck dissection (RR 3.97; 95% CI 1.42\u201311.10), oesophagectomy (RR 9.38; 95% CI 4.13\u201321.3), pharyngectomy (RR 7.14; 95% CI 2.08\u201324.39) and female sex (RR 5.52; 95% CI 1.95\u201315.63) were risk factors for long-term hypoparathyroidism. There was variability in the use of preventative measures, monitoring and management of hypocalcaemia and hypoparathyroidism following total laryngectomy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Transient hypocalcaemia and long-term hypoparathyroidism occur in a significant proportion of patients after laryngectomy. A standard protocol is required to improve care. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2021.0276","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T11:40:31Z","timestamp":1644320431000},"page":"62-67","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of hypoparathyroidism following laryngectomy"],"prefix":"10.1308","volume":"105","author":[{"given":"O","family":"Edafe","sequence":"first","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ET","family":"Tan","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Jackson","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sionis","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SP","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, UK"},{"name":"University of Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Beasley","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"171","reference":[{"key":"C1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12165"},{"key":"C2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9384"},{"key":"C3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2213"},{"key":"C4","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1979"},{"key":"C5","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2273"},{"key":"C6","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06213-2"},{"key":"C7","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2017.09.14"},{"key":"C8","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118001615"},{"key":"C9","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07476-8"},{"key":"C10","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.01.009"},{"key":"C12","volume-title":"Vitamin D and Health","author":"Scientific Advisory Committee on Nutrition","year":"2016"},{"key":"C13","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2017.0194"},{"key":"C14","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.008013"}],"container-title":["The Annals of The Royal College of Surgeons of England"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/pdf\/10.1308\/rcsann.2021.0276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:24:35Z","timestamp":1684146275000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.rcseng.ac.uk\/doi\/10.1308\/rcsann.2021.0276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1308\/rcsann.2021.0276"],"URL":"https:\/\/doi.org\/10.1308\/rcsann.2021.0276","relation":{},"ISSN":["0035-8843","1478-7083"],"issn-type":[{"value":"0035-8843","type":"print"},{"value":"1478-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}