{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:51:37Z","timestamp":1776779497806,"version":"3.51.2"},"reference-count":46,"publisher":"Royal College of Surgeons of England","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["annals"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Literature data indicate a correlation between vitamin D deficiency and thyroid cancer (TC). We conducted this observational study to test this hypothesis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We studied 327 consecutive thyroidectomy cases, and compared patients with TC and those who had benign thyroid disease (BTD). In total, 183 cases with well-differentiated TC (group B) were compared with 144 cases of BTD (group A). We defined 25-hydroxyvitamin D (25(OH)VitD) values &lt;10ng\/ml as severe vitamin D deficiency (15.4%), 10\u201330ng\/ml as inadequacy (70.4%) and &gt;30ng\/ml as adequate (14.2%). We further used a cut-off point of 30ng\/ml (used in a recent meta-analysis) to classify patients as vitamin D deficient or not. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> There was no statistically significant difference in the following: age, size of the thyroid gland, preoperative calcium levels, preoperative parathormone and vitamin D levels, body mass index and anti-thyroid antibodies. Only thyroid-stimulating hormone and weight of the thyroid gland were found to differ. There was no significant difference in mean vitamin D levels (group A = 19.82ng\/ml [sd 9.59] vs group B = 19.69ng\/ml [sd 11.34]; p = 0.917). The same was found when we compared the two groups according to the three categories of vitamin D values (deficiency, inadequacy, adequacy; p = 0.485) and when we performed the analysis based on all threshold levels (10, 20 and 30ng\/ml; p = 0.328). Using various statistical methods, no correlation was found between vitamin D deficiency and differentiated TC (overall, microcarcinomas, macrocarcinomas). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Based on our results, no correlation between vitamin D deficiency and TC was confirmed, contradicting and questioning the results of two recent meta-analyses. <\/jats:p><\/jats:sec>","DOI":"10.1308\/rcsann.2024.0041","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T15:13:11Z","timestamp":1727190791000},"page":"423-428","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin D deficiency and thyroid cancer: is there a true association? 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