{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:50:39Z","timestamp":1760298639311},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cytologic findings of glandular lesions of the cervix uteri are often difficult to evaluate. We studied the usefulness of CINtec PLUS p16\/Ki-67 double stain (mtm laboratories, Heidelberg, Germany) for the diagnosis of glandular lesions. The study included 47 abnormal results on liquid-based cytologic tests with a subsequent histologic diagnosis of adenocarcinoma in situ or with early invasion, and 16 samples with negative results on follow-up. All samples were stained with CINtec PLUS p16\/Ki-67 double stain. Of the neoplastic samples, 7 were excluded because of insufficient residual cellularity or loss of neoplastic cells. Of the samples that were adequate, 92.5% were stained with CINtec PLUS, whereas 7.5% were judged inconclusive. All inconclusive cases were at least 3 years old. Of the 16 negative samples, 15 (93.8%) stained negative and only 1 (6.2%) showed several positive clusters of cells. Our study shows that CINtec PLUS is a robust and useful tool for the diagnosis of glandular lesions of the cervix uteri.<\/jats:p>","DOI":"10.1309\/ajcp00inmgifyfnq","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T16:00:10Z","timestamp":1354723210000},"page":"652-656","source":"Crossref","is-referenced-by-count":20,"title":["CINtec PLUS Immunocytochemistry as a Tool for the Cytologic Diagnosis of Glandular Lesions of the Cervix Uteri"],"prefix":"10.1093","volume":"138","author":[{"given":"Alberto","family":"Ravarino","sequence":"first","affiliation":[{"name":"1Department of Pathology, University Hospital San Giovanni di Dio of Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Nemolato","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University Hospital San Giovanni di Dio of Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Macciocu","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Central Hospital Bolzano, Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Fraschini","sequence":"additional","affiliation":[{"name":"3Department of Electrical and Electronic Engineering, University of Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Senes","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University Hospital San Giovanni di Dio of Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavino","family":"Faa","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University Hospital San Giovanni di Dio of Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Negri","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Central Hospital Bolzano, Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"2023012004412116800_b1-1380652","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/modpathol.3880047","article-title":"Glandular lesions of the uterine cervix","volume":"13","author":"Zaino","year":"2000","journal-title":"Mod Pathol"},{"key":"2023012004412116800_b2-1380652","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00004347-200210000-00004","article-title":"Symposium part III: tumor-like glandular lesions of the uterine cervix","volume":"21","author":"Nucci","year":"2002","journal-title":"Int J Gynecol 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