{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T17:24:08Z","timestamp":1785691448965,"version":"3.56.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To examine the usefulness of the MYD88 L265P somatic mutation in identifying cases of lymphoplasmacytic lymphoma (LPL) from other lymphoplasmacytic neoplasms in bone marrow biopsy specimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We studied 64 bone marrow biopsy specimens with involvement by various small B-cell lymphomas or plasma cell myeloma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The MYD88 L265P somatic mutation was present in 13\/13 cases of LPL, 1\/13 cases of hairy cell leukemia, and absent in the other mature B-cell neoplasms tested. A test set of diagnostically challenging bone marrow cases with lymphoplasmacytoid morphology (B-cell lymphoma, not otherwise specified) was selected for additional review and reclassified, without knowledge of the MYD88 L265P status. Of those 16 cases, 7 were positive for MYD88, including 4\/4 cases that were reclassified as LPL during the review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Although not entirely specific, MYD88 L265P is a useful adjunct for bone marrow diagnosis in separating LPL from other small B-cell lymphomas and plasma cell myeloma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1309\/ajcp10zclfzgyzip","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T23:07:53Z","timestamp":1376694473000},"page":"387-394","source":"Crossref","is-referenced-by-count":52,"title":["<i>MYD88<\/i> L265P Somatic Mutation"],"prefix":"10.1093","volume":"140","author":[{"given":"Sarah L.","family":"Ondrejka","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology, Cleveland Clinic, Cleveland, 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