{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:13:29Z","timestamp":1791213209139,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>The clinical significance of nevus-associated melanoma compared with de novo melanomas remains controversial. It has been suggested that nevus-associated melanomas have a higher Breslow thickness and therefore worse prognosis. Over a 10-year period, this study evaluated the incidence of nevus-associated melanoma and its prognostic significance related to clinicopathologic features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Cross-sectional study from 1995 through 2004 in a dermatopathology referral center. With available data, we evaluated sex, primary location, histologic subtype, Breslow thickness, Clark level, presence of ulceration, associated lesion, and histologic subtype of the associated lesion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of 135,653 pathologic records from skin biopsy specimens over a 10-year period, 1,190 melanoma records were selected. Nevus-associated melanomas corresponded to 390 (32.8%) melanomas, with thin melanomas having a nevus 1.52 times the association observed with thick melanomas (&amp;gt;1.01 mm; 95% confidence interval, 1.16\u20131.99; P &amp;lt; .001). Superficial spreading melanoma was the most frequent, while no lentigo maligna melanoma was associated with nevi. The median Breslow thickness of nevus-associated melanomas was lower than that of de novo melanomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Nevus-associated melanomas, which represent one-third of the melanomas in southeast Brazil, are associated with intermittent sun exposure, superficial spreading melanomas, and lower Breslow thickness. This is one of the largest series describing nevus-associated melanomas in Latin America.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1309\/ajcp4l5cjgktjvdd","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T14:20:53Z","timestamp":1411136453000},"page":"485-491","source":"Crossref","is-referenced-by-count":62,"title":["Nevus-Associated Melanomas"],"prefix":"10.1093","volume":"142","author":[{"given":"Danielle","family":"Shitara","sequence":"first","affiliation":[{"name":"1Department of Dermatology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio M.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"2Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain and CIBER de Enfermedades Raras, Instituto de Salud Carlos III, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Yamada","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milvia M. S. S.","family":"Enokihara","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"3Department of Pathology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilceo","family":"Michalany","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"3Department of Pathology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edil\u00e9ia","family":"Bagatin","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, 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