{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:14:01Z","timestamp":1788952441319,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To investigate whether discriminating the classic perinuclear antineutrophil cytoplasmic antibody (P-ANCA) pattern from atypical P-ANCA and uninterpretable patterns improves the diagnostic utility of ANCA testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>All ANCA requests (n = 3,544) referred to Pathology Queensland were analyzed prospectively over 4 months for P-ANCA pattern subtypes and myeloperoxidase (MPO)-ANCA\/PR3-ANCA results and correlated with clinical, laboratory, and radiologic evidence of necrotizing small vessel vasculitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of the 436 perinuclear immunofluorescence-positive samples, 45 were classic P-ANCA, 163 were atypical P-ANCA, and 228 were antinuclear antibodies\/uninterpretable. The classic P-ANCA pattern had a significantly stronger association with vasculitis (30\/45) than atypical P-ANCA (2\/163) (P &amp;lt;.0001) or ANA\/uninterpretable patterns (8\/228) (P &amp;lt;.0001). The combination of a classic P-ANCA pattern and positive MPO-ANCA\/PR3-ANCA result was also more strongly associated with vasculitis than a positive MPO-ANCA\/PR3-ANCA result in isolation (P = .003).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>This study demonstrates that reporting different P-ANCA patterns (including ANA\/uninterpretable patterns) provides additional diagnostic information to MPO-ANCA\/PR3-ANCA results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1309\/ajcp4y8admkoscxv","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T19:43:29Z","timestamp":1375127009000},"page":"184-192","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic Value of Distinguishing and Reporting Different Perinuclear ANCA (P-ANCA) Immunofluorescence Patterns"],"prefix":"10.1093","volume":"140","author":[{"given":"Susan B.","family":"Perel","sequence":"first","affiliation":[{"name":"1Division of Immunology, HSSA Pathology Queensland Central Laboratory, Royal Brisbane and Women\u2019s Hospital, Herston, Queensland, Australia"},{"name":"2Department of Clinical Immunology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri M.","family":"Prain","sequence":"additional","affiliation":[{"name":"1Division of Immunology, HSSA Pathology Queensland Central Laboratory, Royal Brisbane and Women\u2019s Hospital, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"1Division of Immunology, HSSA Pathology Queensland Central Laboratory, Royal Brisbane and Women\u2019s Hospital, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick G.","family":"Hogan","sequence":"additional","affiliation":[{"name":"1Division of Immunology, HSSA Pathology Queensland Central Laboratory, Royal Brisbane and Women\u2019s Hospital, Herston, Queensland, Australia"},{"name":"2Department of Clinical Immunology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gillis","sequence":"additional","affiliation":[{"name":"1Division of Immunology, HSSA Pathology Queensland Central Laboratory, Royal Brisbane and Women\u2019s Hospital, Herston, Queensland, Australia"},{"name":"2Department of Clinical Immunology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C. 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