{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:32:13Z","timestamp":1775327533053,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non\u2013Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression during the clinical course of DLBCL (group 1). Three cases showed transformation from CD5\u2212 low-grade B-cell lymphoma to CD5+ DLBCL (group 2). The remaining case showed coexistence of CD5+ DLBCL and CD5+ follicular lymphoma. The clonal relationships of CD5\u2212 and CD5+ tumors were confirmed in all 4 available cases. Cases of secondary CD5+ DLBCL that were not Richter syndrome were classifiable into 3 groups. Groups 1 and 2 showed the gain of CD5 during the clinical course or transformation of the tumors, suggesting that CD5 expression is closely associated with the progression of B-cell lymphoma.<\/jats:p>","DOI":"10.1309\/ajcp58fetfglckkw","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T01:59:41Z","timestamp":1235008781000},"page":"339-346","source":"Crossref","is-referenced-by-count":14,"title":["Secondary CD5+ Diffuse Large B-Cell Lymphoma Not Associated With Transformation of Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (Richter Syndrome)"],"prefix":"10.1093","volume":"131","author":[{"given":"Akiko Miyagi","family":"Maeshima","sequence":"first","affiliation":[{"name":"1Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"1Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nomoto","sequence":"additional","affiliation":[{"name":"2Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Maruyama","sequence":"additional","affiliation":[{"name":"2Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"2Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"2Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"2Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensei","family":"Tobinai","sequence":"additional","affiliation":[{"name":"2Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Matsuno","sequence":"additional","affiliation":[{"name":"3Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2023012007394382800_b1-1310339","first-page":"823","article-title":"Follicular lymphoma","volume-title":"Neoplastic 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