{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:04:21Z","timestamp":1777525461319,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effect of age on Hybrid Capture 2 (HC2) tests initially falling within the equivocal range has not been determined. We identified 359 cervicovaginal liquid cytology specimens with initial equivocal values. First and second retest relative light units\/cutoff (RLU\/CO) values were compared for women of 3 different age groups (15\u201329, 30\u201349, and \u226550 years). The proportion of first retests with an RLU\/CO of less than 1 increased with age (P &amp;lt; .001). Of the 56 second retests performed, only 4 had an RLU\/CO of 1 or more. The proportion of \u201cpositive\u201d HC2 results following the current HC2 algorithm decreased with increasing age (P &amp;lt; .001), showing that HC2 test results after an initial equivocal value are dependent on age. Follow-up demonstrated cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in 6 (5.9%) women 15 to 29 years old and in 5 (6.3%) women 30 to 49 years old. No CIN2+ was found on follow-up of 34 of 57 women 50 years and older. These results likely reflect human papillomavirus infection prevalence and question the use of identical cutoff values regardless of age for detection of CIN2+.<\/jats:p>","DOI":"10.1309\/ajcparhtb40dtvfv","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T20:33:19Z","timestamp":1366230799000},"page":"605-610","source":"Crossref","is-referenced-by-count":2,"title":["Hybrid Capture 2 Test Results After an Initial Equivocal RLU\/CO Value Are Dependent on Age"],"prefix":"10.1093","volume":"139","author":[{"given":"Camille T.","family":"Elkins","sequence":"first","affiliation":[{"name":"1Department of Pathology, The Ohio State University College of Medicine, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiaan E.","family":"de Vries","sequence":"additional","affiliation":[{"name":"1Department of Pathology, The Ohio State University College of Medicine, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Stephens","sequence":"additional","affiliation":[{"name":"2Center of Biostatistics, The Ohio State University College of Medicine, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian A.","family":"Suarez","sequence":"additional","affiliation":[{"name":"1Department of Pathology, The Ohio State University College of Medicine, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"key":"2023012006395973100_b1-1390605","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/jnci\/djq562","article-title":"Human papillomavirus testing in the prevention of cervical cancer","volume":"103","author":"Schiffman","year":"2011","journal-title":"J Natl Cancer 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