{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:07:49Z","timestamp":1789880869574,"version":"4.0.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Follicular lymphoma (FL) involving the spleen must be distinguished from reactive hyperplasia and from other lymphomas. A prior study reported that splenic FLs frequently lack BCL2 expression, further complicating diagnosis. We examined 16 cases of splenic FL, including 12 cases initially diagnosed at splenectomy. Two morphologic patterns were identified: one with architectural abnormalities (AA) and one with an extensive architectural preservation (AP) pattern. Newly diagnosed AP cases were associated with older age (P = .051) and grade 1 histologic features (P = .023). All cases displayed a CD10+\/BCL2+ phenotype. Cytogenetics and FISH identified IGH\/BCL2 or BCL6 translocations in all tested cases. Splenic FLs display phenotypic and cytogenetic findings similar to nodal FLs. However, splenic FLs frequently display an exclusively intrafollicular growth pattern resembling so-called in situ FL. Recognition of subtle FL with preserved architecture is important because patients may have overt FL at other sites or the FL may progress to overt nodal disease.<\/jats:p>","DOI":"10.1309\/ajcpf9v8xrdywtir","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T18:43:53Z","timestamp":1239821033000},"page":"656-662","source":"Crossref","is-referenced-by-count":30,"title":["Follicular Lymphoma of the Spleen"],"prefix":"10.1093","volume":"131","author":[{"given":"Matthew T.","family":"Howard","sequence":"first","affiliation":[{"name":"1Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Dufresne","sequence":"additional","affiliation":[{"name":"2Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"2Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cook","sequence":"additional","affiliation":[{"name":"1Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"2023011907331120600_b1-1310656","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hon.762","article-title":"Nodal and splenic marginal zone B cell lymphomas","volume":"23","author":"Mollejo","year":"2005","journal-title":"Hematol Oncol"},{"key":"2023011907331120600_b2-1310656","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/sj.leu.2405068","article-title":"Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria","volume":"22","author":"Matutes","year":"2008","journal-title":"Leukemia"},{"key":"2023011907331120600_b3-1310656","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/1097-0142(20010601)91:11<2001::AID-CNCR1225>3.0.CO;2-3","article-title":"The spleen as a diagnostic specimen: a review of 10 years\u2019 experience at two tertiary care institutions","volume":"91","author":"Kraus","year":"2001","journal-title":"Cancer"},{"key":"2023011907331120600_b4-1310656","first-page":"18","article-title":"Non-Hodgkin\u2019s lymphoproliferative disorders involving the spleen","volume":"10","author":"Arber","year":"1997","journal-title":"Mod Pathol"},{"key":"2023011907331120600_b5-1310656","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1046\/j.1365-2559.1998.00478.x","article-title":"A marginal zone pattern may be found in different varieties of non-Hodgkin\u2019s lymphoma: the morphology and immunohistology of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma","volume":"33","author":"Piris","year":"1998","journal-title":"Histopathology"},{"key":"2023011907331120600_b6-1310656","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1309\/HWG084N3F3LRJ8XB","article-title":"Histopathologic features of splenic small B-cell lymphomas: a study of 42 cases with a definitive diagnosis by the World Health Organization classification","volume":"120","author":"Kansal","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"2023011907331120600_b7-1310656","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00000478-199602000-00010","article-title":"\u201cSmall\u201d B-cell non-Hodgkin\u2019s lymphomas with splenomegaly at presentation are either mantle cell lymphoma or marginal zone cell lymphoma: a study based on histology, cytology, immunohistochemistry, and cytogenetic analysis","volume":"20","author":"Pittaluga","year":"1996","journal-title":"Am J Surg Pathol\u201d"},{"key":"2023011907331120600_b8-1310656","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/sj.leu.2404426","article-title":"Molecular pathways in follicular lymphoma","volume":"21","author":"Bende","year":"2007","journal-title":"Leukemia"},{"key":"2023011907331120600_b9-1310656","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.blre.2004.09.001","article-title":"Follicular lymphoma: time for a re-think?","volume":"19","author":"Gandhi","year":"2005","journal-title":"Blood Rev"},{"key":"2023011907331120600_b10-1310656","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/sj.leu.2403738","article-title":"Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances","volume":"19","author":"Guo","year":"2005","journal-title":"Leukemia"},{"key":"2023011907331120600_b11-1310656","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2008"},{"key":"2023011907331120600_b12-1310656","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.0303-6987.2006.00459.x","article-title":"t(14;18)(Q32;Q21) involving IGH and MALT1 is uncommon in cutaneous malt lymphomas and primary cutaneous diffuse large B-cell lymphomas","volume":"33","author":"Wongchaowart","year":"2006","journal-title":"J Cutan Pathol"},{"key":"2023011907331120600_b13-1310656","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1182\/blood.V99.9.3376","article-title":"In situ localization of follicular lymphoma: description and analysis by laser capture microdissection","volume":"99","author":"Cong","year":"2002","journal-title":"Blood"},{"key":"2023011907331120600_b14-1310656","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2141.2007.06671.x","article-title":"Distribution of t(14;18)-positive, putative lymphoma precursor cells among B-cell subsets in healthy individuals","volume":"138","author":"Hirt","year":"2007","journal-title":"Br J Haematol"},{"key":"2023011907331120600_b15-1310656","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1084\/jem.20061292","article-title":"Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis","volume":"203","author":"Roulland","year":"2006","journal-title":"J Exp Med"},{"key":"2023011907331120600_b16-1310656","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1182\/blood.V85.9.2528.bloodjournal8592528","article-title":"Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals","volume":"85","author":"Limpens","year":"1995","journal-title":"Blood"},{"key":"2023011907331120600_b17-1310656","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1200\/JCO.2001.19.2.420","article-title":"Frequency of the BCL2\/IGH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma","volume":"19","author":"Summers","year":"2001","journal-title":"J Clin Oncol"},{"key":"2023011907331120600_b18-1310656","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.leukres.2005.10.001","article-title":"The BCL2\/IGH rearrangement in a population of 204 healthy individuals: occurrence, age and gender distribution, breakpoints, and detection method validity","volume":"30","author":"Schmitt","year":"2006","journal-title":"Leuk Res"},{"key":"2023011907331120600_b19-1310656","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1200\/JCO.2003.07.070","article-title":"PCR-detectable nonneoplastic BCL-2\/IGH rearrangements are common in normal subjects and cancer patients at diagnosis but rare in subjects treated with chemotherapy","volume":"21","author":"Ladetto","year":"2003","journal-title":"J Clin Oncol"},{"issue":"S1","key":"2023011907331120600_b20-1310656","first-page":"266A","article-title":"Splenic follicular lymphomas: a clinicopathologic study of 33 cases [abstract]","volume":"21","author":"Mollejo","year":"2008","journal-title":"Mod Pathol"}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/131\/5\/656\/48764026\/ajcp_131_5_656.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/131\/5\/656\/48764026\/ajcp_131_5_656.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T07:33:27Z","timestamp":1674113607000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/131\/5\/656\/1765947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,1]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,5,1]]},"published-print":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1309\/ajcpf9v8xrdywtir","relation":{},"ISSN":["1943-7722","0002-9173"],"issn-type":[{"value":"1943-7722","type":"electronic"},{"value":"0002-9173","type":"print"}],"subject":[],"published-other":{"date-parts":[[2009,5,1]]},"published":{"date-parts":[[2009,5,1]]}}}