{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:09:11Z","timestamp":1770822551063,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The diagnosis of myelodysplastic syndromes (MDSs) relies largely on morphologic and karyotypic abnormalities, present in about 50% of patients with MDS. Array-based genomic platforms have identified copy number alterations in 50% to 70% of bone marrow samples of patients with MDS with a normal karyotype, suggesting a diagnostic role for these platforms. We investigated whether blood granulocytes harbor the same copy number alterations as the marrow of affected patients. Of 11 patients, 4 had cytogenetic abnormalities shown by conventional karyotyping involving chromosomes 5, 8, 11, 20, and X, and these changes were seen in the granulocytes of all 4 patients by using array comparative genomic hybridization (aCGH). Cryptic alterations were identified at a significantly higher level in marrow CD34+ cells compared with granulocytes (P &amp;lt; .0001). These data suggest that aCGH analysis of circulating granulocytes may be useful in detecting gross karyotypic alterations in patients with MDS when marrow examination has failed or not been done.<\/jats:p>","DOI":"10.1309\/ajcph27zizejlorf","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T16:59:18Z","timestamp":1276621158000},"page":"119-126","source":"Crossref","is-referenced-by-count":11,"title":["Array Comparative Genomic Hybridization of Peripheral Blood Granulocytes of Patients With Myelodysplastic Syndrome Detects Karyotypic Abnormalities"],"prefix":"10.1093","volume":"134","author":[{"given":"Suzanne M.","family":"Vercauteren","sequence":"first","affiliation":[{"name":"1Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Canada"},{"name":"4Department of Medical Biophysics, Vancouver, Canada"},{"name":"5Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Sung","sequence":"additional","affiliation":[{"name":"4Department of Medical Biophysics, Vancouver, Canada"},{"name":"5Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel T.","family":"Starczynowski","sequence":"additional","affiliation":[{"name":"4Department of Medical Biophysics, Vancouver, Canada"},{"name":"5Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada"},{"name":"6Department of Pathology and Laboratory Medicine, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan L.","family":"Lam","sequence":"additional","affiliation":[{"name":"7Department of Cancer Genetics and Developmental Biology, Vancouver, Canada"},{"name":"8Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Bruyere","sequence":"additional","affiliation":[{"name":"1Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Canada"},{"name":"2Department of Cytogenetics, Vancouver General Hospital, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas E.","family":"Horsman","sequence":"additional","affiliation":[{"name":"7Department of Cancer Genetics and Developmental Biology, Vancouver, Canada"},{"name":"8Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tsang","sequence":"additional","affiliation":[{"name":"3Department of Hematology, Vancouver General Hospital, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Leitch","sequence":"additional","affiliation":[{"name":"9Division of 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