{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:38:10Z","timestamp":1770136690010,"version":"3.49.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>To report a patient with primary effusion lymphoma who was negative for human herpesvirus-8 (HHV-8), human immunodeficiency virus, Epstein-Barr virus, hepatitis C virus, and hepatitis B virus, as well as review 54 reported cases of HHV-8\u2013unrelated primary effusion lymphoma (PEL)\u2013like lymphoma in the literature to clarify the nature of this entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The patients\u2019 characteristics, clinical presentation, pathogenesis, morphologic-immunophenotypic features, clinical management, and prognosis were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>HHV-8\u2013negative PEL-like lymphomas often occur in immunocompetent and elderly patients, are sometimes associated with chronic inflammation\u2013related fluid overload, are mostly large B-cell or large B-cell with plasmacytic differentiation type, and are associated with a better prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In various aspects, HHV-8\u2013unrelated PEL-like lymphoma is a different entity from HHV-8\u2013related PEL. Immunophenotype, morphology, and c-myc\/8q24 status should be included for differential diagnosis. A test for c-myc or 8q24 abnormalities should be recommended for subdividing HHV-8\u2013unrelated PEL-like lymphoma, which may have benefits in patient management.<\/jats:p><\/jats:sec>","DOI":"10.1309\/ajcphz3cho4huwet","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T19:43:29Z","timestamp":1375127009000},"page":"258-273","source":"Crossref","is-referenced-by-count":68,"title":["Human Herpesvirus 8\u2013Unrelated Primary Effusion Lymphoma\u2013Like Lymphoma"],"prefix":"10.1093","volume":"140","author":[{"given":"William","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California, Irvine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonita","family":"Youm","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California, Irvine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif 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