{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:07:18Z","timestamp":1762866438410},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>Acute myeloid leukemia (AML) with monosomal karyotype (MK) recently has been reported to be associated with worse outcome than the traditional complex karyotype.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>In this retrospective study of 111 patients with AML, we identified 14 patients with MK (13% of all patients with AML) using the definition proposed by Breems et al.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Five (36%) of these 14 patients had a loss of a single chromosome in the presence of other structural abnormalities, and nine (64%) had a loss of two or more autosomal chromosomes. Patients with AML-MK presented at an older age, with lower bone marrow blasts, and their blasts less frequently expressed CD34. Most patients with AML-MK had morphologic multilineage dysplasia and were predominantly subclassified as having AML with myelodysplasia-related changes (AML-MRC). Molecular analysis showed a significant absence of NPM1 and FLT3 in patients with AML-MK.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Outcome data showed that patients with AML-MK had significantly worse overall survival, disease-free survival, and complete response compared with the rest of the patients with AML as well as within the AML-MRC group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1309\/ajcpmlo84jdnvlnk","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T19:19:07Z","timestamp":1405106347000},"page":"190-195","source":"Crossref","is-referenced-by-count":20,"title":["Acute Myeloid Leukemia With Monosomal Karyotype"],"prefix":"10.1093","volume":"142","author":[{"given":"Olga K.","family":"Weinberg","sequence":"first","affiliation":[{"name":"1Boston Children\u2019s Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Ohgami","sequence":"additional","affiliation":[{"name":"2Stanford University Medical Center, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Ma","sequence":"additional","affiliation":[{"name":"2Stanford University Medical Center, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Seo","sequence":"additional","affiliation":[{"name":"2Stanford University Medical Center, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ren","sequence":"additional","affiliation":[{"name":"2Stanford University Medical Center, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R.","family":"Gotlib","sequence":"additional","affiliation":[{"name":"2Stanford University Medical Center, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Seetharam","sequence":"additional","affiliation":[{"name":"3Arizona Oncology, Scottsdale, AZ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athena","family":"Cherry","sequence":"additional","affiliation":[{"name":"2Stanford University Medical Center, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Arber","sequence":"additional","affiliation":[{"name":"2Stanford University Medical Center, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"2023012007524966900_b1-1420190","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0268-960X(03)00040-7","article-title":"Cytogenetics in acute leukemia","volume":"18","author":"Mrozek","year":"2004","journal-title":"Blood 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influencing the outcome of acute myeloid leukemia: analysis of 848 patients","volume":"15","author":"Visani","year":"2001","journal-title":"Leukemia"},{"key":"2023012007524966900_b5-1420190","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1182\/blood-2002-03-0772","article-title":"Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALBG 8461)","volume":"100","author":"Byrd","year":"2002","journal-title":"Blood"},{"key":"2023012007524966900_b6-1420190","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1200\/JCO.2008.16.0259","article-title":"Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype","volume":"26","author":"Breems","year":"2008","journal-title":"J Clin 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