{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T08:59:03Z","timestamp":1698829143750},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our aim was to evaluate the usefulness of the monoclonal antibody Das-1 as a premalignant marker of gastric intestinal metaplasia (GIM) associated with gastric cancer and its association with mucin expression.<\/jats:p>\n               <jats:p>We evaluated Das-1 and mucin expression in 4 groups: 1 (n = 50), gastric carcinoma, paired samples of the cancer area and GIM away from the tumor; 2 (n = 25), gastric or duodenal ulcer with Helicobacter pylori infection with GIM and chronic gastritis; 3 (n = 25), H pylori\u2013autoimmune chronic atrophic gastritis with GIM; and 4 (n = 25), H pylori\u2013chronic gastritis without GIM.<\/jats:p>\n               <jats:p>Das-1 immunostaining was observed in 20 (40%) of 50 cases in cancer areas. The expression of Das-1 in GIM from group 1 cases away from the cancer area was different from that in GIM from nontumor cases (groups 2 and 3): 13 (26%) of 50 vs 2 (8%) and 0 (0%) of 25 (P = .004). There was no association between Das-1 and mucin expression.<\/jats:p>\n               <jats:p>Das-1 expression was associated with GIM from patients with gastric cancer. However, this relation was weaker than previously reported, precluding clinical usefulness as a premalignant marker of GIM.<\/jats:p>","DOI":"10.1309\/ajcpnp7bk3kuuojl","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T02:15:17Z","timestamp":1229652917000},"page":"99-105","source":"Crossref","is-referenced-by-count":3,"title":["Lack of Clinical Usefulness of Das-1 Monoclonal Antibody and Mucin Expression as Risk Markers of Gastric Carcinoma in Patients With Gastric Intestinal Metaplasia"],"prefix":"10.1093","volume":"131","author":[{"given":"Montserrat","family":"Forn\u00e9","sequence":"first","affiliation":[{"name":"1Departments of Gastroenterology, Hospital Universitari M\u00fatua Terrassa, Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Fern\u00e1ndez-Ba\u00f1ares","sequence":"additional","affiliation":[{"name":"1Departments of Gastroenterology, Hospital Universitari M\u00fatua Terrassa, Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarisa","family":"Gonz\u00e1lez-M\u00ednguez","sequence":"additional","affiliation":[{"name":"2Pathology, Hospital Universitari M\u00fatua Terrassa, Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Casalots","sequence":"additional","affiliation":[{"name":"2Pathology, Hospital Universitari M\u00fatua Terrassa, Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Poblet-Mas","sequence":"additional","affiliation":[{"name":"3Laboratory of Molecular Microbiology, Department of Biology, University of Girona, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jes\u00fas","family":"Garcia-Gil","sequence":"additional","affiliation":[{"name":"3Laboratory of Molecular Microbiology, Department of Biology, University of Girona, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Esteve","sequence":"additional","affiliation":[{"name":"1Departments of Gastroenterology, Hospital Universitari M\u00fatua Terrassa, Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Rosinach","sequence":"additional","affiliation":[{"name":"1Departments of Gastroenterology, Hospital Universitari M\u00fatua Terrassa, Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Espin\u00f3s","sequence":"additional","affiliation":[{"name":"1Departments of Gastroenterology, Hospital Universitari M\u00fatua Terrassa, Terrassa, 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