{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:29:21Z","timestamp":1780630161662,"version":"3.54.1"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report 10 cases of donor cell leukemia (DCL). All cases except the case of chronic lymphocytic leukemia had anemia, neutropenia, and\/or thrombocytopenia when DCL was diagnosed. Eight cases with sex-mismatched hematopoietic stem cell transplant (HCT) showed donor gonosomal complements, suggesting DCL. Clonal cytogenetic abnormalities were detected in 8 cases: 6 were monosomy 7\/del(7q). In all 10 cases, engraftment studies confirmed donor cell origin. Retrospective fluorescence in situ hybridization in archived donor cells in 4 cases showed a low level of abnormalities in 2. Of 7 patients with clinical follow-up of 5 months or more, 1 (with acute myeloid leukemia) died of disease; 6 are alive, including 1 with myelodysplastic syndrome with spontaneous remission. Similar to reported cases, we found disproportional sex-mismatched HCTs, suggesting probable underdetection of DCL in sex-matched HCTs. The latency between HCT and DCL ranged from 1 to 193 months (median, 24 months), in keeping with the literature. Analyzing our cases, pooled with reported cases, with survival models showed much shorter latency for malignancy as primary disease, for T-cell large granular lymphocyte leukemia as type of DCL, and for umbilical cord blood as stem cell source.<\/jats:p>","DOI":"10.1309\/ajcppjuq9dnr1ghp","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T23:39:51Z","timestamp":1300318791000},"page":"525-540","source":"Crossref","is-referenced-by-count":59,"title":["Donor Cell\u2013Derived Leukemias\/Myelodysplastic Neoplasms in Allogeneic Hematopoietic Stem Cell Transplant Recipients"],"prefix":"10.1093","volume":"135","author":[{"given":"Endi","family":"Wang","sequence":"first","affiliation":[{"name":"1Department of Pathology, Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Blake","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Duke University Medical 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