{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T22:35:36Z","timestamp":1717022136303},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neoplastic melanocytes may exhibit certain differentiation characteristics of other neural-crest derivatives. We aimed to study the expression of microtubule-associated protein 2 (MAP-2) in different types of melanocytic skin lesions. Paraffin-embedded sections of 42 benign nevi (BN), 22 dysplastic nevi (DN), 45 superficial spreading melanomas (SSMs), and 15 subcutaneous melanoma metastases were immunohistologically assessed using the monoclonal mouse MAP-2ab antibody (Zytomed, Berlin, Germany). The percentage MAP-2 expression of DN and SSMs was significantly increased compared with BN. Moreover, subcutaneous melanoma metastases showed significantly decreased MAP-2 expression compared with DN and SSMs. In SSMs, MAP-2 expression significantly correlated with the Breslow vertical tumor thickness, Clark level, and stage of disease. We observed that MAP-2 is differentially expressed during the development and progression of benign and malignant melanocytic skin lesions. In contrast with the findings of previous studies, our data indicate that MAP-2 is a moderately positive predictor of the progression of SSMs.<\/jats:p>","DOI":"10.1309\/ajcpr84ulyvmnjhg","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T18:43:53Z","timestamp":1239821033000},"page":"710-714","source":"Crossref","is-referenced-by-count":8,"title":["Differential Expression of Microtubule-Associated Protein 2 in Melanocytic Skin Lesions"],"prefix":"10.1093","volume":"131","author":[{"given":"Thilo","family":"Gambichler","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Rotterdam","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Radkowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Altmeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"2023011907331308100_b1-1310710","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4065\/81.4.500","article-title":"Cutaneous malignant 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