{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:36:11Z","timestamp":1789205771279,"version":"build-2803163510"},"reference-count":183,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Session 2 of the 2007 Workshop of the Society for Hematopathology\/European Association for Haematopathology was focused on Philadelphia chromosome\u2013negative chronic myeloproliferative diseases (Ph\u2013 MPDs), recently termed chronic myeloproliferative neoplasms. The presented and submitted cases highlighted some important issues and also impending problems associated with the diagnosis and classification. Cases included predominantly rare entities like chronic eosinophilic leukemia and related disorders, chronic neutrophilic leukemia, and others with specific genetic abnormalities that allowed molecularly targeted therapy. In this context, the distinctive role of a positive JAK2V617F mutation for the diagnosis of Ph\u2013 MPD was underscored, including entities with a low allele burden and the discrimination from reactive disorders (autoimmune myelofibrosis, reactive thrombocytosis). Although novel genetic and molecular approaches have significantly improved the way we classify Ph\u2013 MPD, a combined clinicopathologic approach, including representative bone marrow specimens, still remains the yardstick for diagnosis.<\/jats:p>","DOI":"10.1309\/ajcpr8ginmbdg9yg","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T21:43:54Z","timestamp":1247694234000},"page":"261-280","source":"Crossref","is-referenced-by-count":28,"title":["Philadelphia Chromosome\u2013Negative Chronic Myeloproliferative Disease"],"prefix":"10.1093","volume":"132","author":[{"given":"Juergen","family":"Thiele","sequence":"first","affiliation":[{"name":"Institute of Pathology, University of Cologne, Cologne, 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