{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:08:41Z","timestamp":1761844121098},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Spectrins are large, rod-like, multifunctional molecules that participate in maintaining cell structure, signal transmission, and DNA repair. Because little is known about the role of spectrins in normal hematopoiesis and leukemogenesis, we immunohistochemically stained bone marrow biopsy specimens from 81 patients for \u03b1I, \u03b1II, \u03b2I, and \u03b2II spectrin isoforms in normal reactive marrow (NRM), myelodysplastic syndrome, myeloproliferative neoplasm, acute myeloid leukemia (AML) with well-characterized cytogenetic abnormalities, acute erythroid leukemia (EryL), and acute megakaryoblastic leukemia (MegL). In NRM, spectrin isoforms were differentially expressed according to cell lineage: \u03b1I and \u03b2I in erythroid precursors; \u03b1II and \u03b2II in granulocytes; and \u03b2I and \u03b2II in megakaryocytes. In contrast, 18 (44%) of 41 AMLs lacked \u03b1II spectrin and\/or aberrantly expressed \u03b2I spectrin (P = .0398; Fisher exact test) and 5 (100%) of 5 EryLs expressed \u03b2II spectrin but lacked \u03b2I spectrin. The frequent loss and\/or gain of spectrin isoforms in AMLs suggests a possible role for spectrin in leukemogenesis.<\/jats:p>","DOI":"10.1309\/ajcpsa5rnm9igfjf","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T16:42:07Z","timestamp":1310661727000},"page":"300-308","source":"Crossref","is-referenced-by-count":14,"title":["Spectrin Isoforms"],"prefix":"10.1093","volume":"136","author":[{"given":"Lucia R.","family":"Wolgast","sequence":"first","affiliation":[{"name":"1Department of Pathology, Montefiore Medical Center, Bronx, NY"},{"name":"2Department of Pathology, Albert Einstein College of Medicine, Bronx"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda A.","family":"Cannizzarro","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Montefiore Medical Center, Bronx, NY"},{"name":"2Department of Pathology, Albert Einstein College of Medicine, Bronx"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Ramesh","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Montefiore Medical Center, Bronx, NY"},{"name":"2Department of Pathology, Albert Einstein College of Medicine, Bronx"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Xue","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Albert Einstein College of Medicine, Bronx"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Albert Einstein College of Medicine, Bronx"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritish K.","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"3Department of Pathology, Hackensack University Medical Center, Hackensack, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerald Z.","family":"Gong","sequence":"additional","affiliation":[{"name":"4Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"McMahon","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Montefiore Medical Center, Bronx, NY"},{"name":"2Department of Pathology, Albert Einstein College of Medicine, Bronx"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Albanese","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Montefiore Medical Center, Bronx, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya L.","family":"Sunkara","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Montefiore Medical Center, Bronx, 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