{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:26:55Z","timestamp":1789608415243,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Human herpesvirus 8 (HHV8)\u2013associated lymphomas are uncommon, mainly affect men infected with the human immunodeficiency virus (HIV), and usually have a poor prognosis. We sought to characterize the HHV8+ lymphomas seen at our institution since the mid-1990s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We identified 15 patients with HHV8-associated lymphomas and evaluated their clinical and pathologic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Diagnoses included primary effusion lymphoma (PEL) (n = 2), extracavitary PEL (n = 8), intravascular large B-cell lymphoma (n = 1), HHV8+ plasmablastic microlymphoma (n = 3), and germinotropic lymphoproliferative disorder (GLD) (n = 1). The case of GLD progressed to a high-grade HHV8+ Epstein-Barr virus\u2013positive lymphoma, an evolution that has not been previously reported. Four patients were HIV\u2212(three from an HHV8-endemic area). Potentially misleading pathologic features in our series of extracavitary PEL included classic Hodgkin lymphoma\u2013like features, lymph node sinus involvement, and T-cell antigen expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>HHV8-associated lymphomas can be clinically and pathologically heterogeneous, with features that may lead to misdiagnosis as other types of lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1309\/ajcpuli3w6wuggpy","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T20:19:20Z","timestamp":1415737160000},"page":"816-829","source":"Crossref","is-referenced-by-count":56,"title":["Diverse Clinicopathologic Features in Human Herpesvirus 8\u2013Associated Lymphomas Lead to Diagnostic Problems"],"prefix":"10.1093","volume":"142","author":[{"given":"Elizabeth L.","family":"Courville","sequence":"first","affiliation":[{"name":"James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyah R.","family":"Sohani","sequence":"additional","affiliation":[{"name":"James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Hasserjian","sequence":"additional","affiliation":[{"name":"James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence R.","family":"Zukerberg","sequence":"additional","affiliation":[{"name":"James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Harris","sequence":"additional","affiliation":[{"name":"James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Ferry","sequence":"additional","affiliation":[{"name":"James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"key":"2023012005501819600_b1-1420816","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2141.2007.06879.x","article-title":"KSHV\/HHV8-associated lymphomas","volume":"140","author":"Carbone","year":"2008","journal-title":"Br J 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