{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:13:00Z","timestamp":1785928380988,"version":"3.56.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mantle cell lymphoma (MCL) expresses pan\u2013B-cell antigens and is usually CD5+\/CD10\u2212\/CD23\u2212\/FMC7+. In this study, we evaluated 52 patients with confirmed diagnoses of MCL and identified variant immunophenotypes in 21 patients (19\/48 classical and 2\/4 variant MCLs), including CD5\u2212 in 6 (12%) of 52, CD10+ in 4 (8%) of 50, CD23+ in 10 (21%) of 48, and FMC7\u2212 in 4 (11%) of 37 cases. Three cases showed variations in 2 antigens, including CD5\u2212\/CD23+, CD10+\/FMC7\u2212, and CD23+\/FMC7\u2212; they were all classical MCLs. One blastoid variant MCL was CD23+, and one was FMC7\u2212. Evaluation for proliferation index by immunohistochemical analysis for Ki-67 demonstrated no significant difference between MCLs with variant immunophenotypes and MCLs with typical immunophenotypes. The high proliferation index (&amp;gt;60%) was exclusively seen in the blastoid and pleomorphic variants. Our results indicate that immunophenotypic variations are common in MCL, and recognizing the variability is important for accurate subclassification of B-cell lymphoma.<\/jats:p>","DOI":"10.1309\/ajcpv8ln5enmzovy","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T19:43:36Z","timestamp":1256154216000},"page":"699-706","source":"Crossref","is-referenced-by-count":78,"title":["Immunophenotypic Variations in Mantle Cell Lymphoma"],"prefix":"10.1093","volume":"132","author":[{"given":"Juehua","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LoAnn","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, 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