{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T23:12:42Z","timestamp":1769641962206,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The lamellar body count (LBC) represents an alternative method to the TDx-FLM II (Abbott Laboratories, Abbott Park, IL), which is planned to be discontinued, for assessing fetal lung maturity. Our objective was to validate the LBC on 3 hematology analyzers (Coulter LH 750 and Coulter Ac\u00b7T diff2, Beckman Coulter, Brea, CA; and Sysmex XE-2100, Sysmex, Mundelein, IL) to serve as a template for other laboratories attempting to perform in-house validation.<\/jats:p>\n               <jats:p>Intra-assay and interassay coefficients of variation ranged from 1.7% to 21.8% and 1.9% to 7.1%, respectively, and all analyzers demonstrated excellent linearity. Whole blood and meconium were shown to interfere with LBCs, and specimens with these contaminants should be tested using phosphatidyl glycerol. With a TDx-FLM II cutoff of 55 mg\/g or more and an LBC cutoff of 50,000\/\u03bcL or more for maturity, concordance between the TDx-FLM II and the LBC on all instruments was poor (&amp;lt;80% in all cases). Concordance between hematology analyzers was excellent (\u226594%). When laboratories are performing in-house validations, they should not correlate LBC with TDx-FLM II results without outcome data. Correlation with another validated LBC method is preferred.<\/jats:p>","DOI":"10.1309\/ajcpweuim2cwuov8","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T02:58:04Z","timestamp":1282100284000},"page":"420-428","source":"Crossref","is-referenced-by-count":14,"title":["Validation of Lamellar Body Counts Using Three Hematology Analyzers"],"prefix":"10.1093","volume":"134","author":[{"given":"Christina M.","family":"Lockwood","sequence":"first","affiliation":[{"name":"1Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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