{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:16:57Z","timestamp":1763036217915},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Clin Pathol"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1309\/unxjvamv77jam4fm","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T20:20:34Z","timestamp":1175286034000},"page":"931-940","source":"Crossref","is-referenced-by-count":9,"title":["Detection of the t(11;18) API2\/MALT1 Translocation Associated With Gastric MALT Lymphoma in Routine Formalin-Fixed, Paraffin-Embedded Small Endoscopic Biopsy Specimens by Robust Real-Time RT-PCR"],"prefix":"10.1093","volume":"126","author":[{"given":"Weisu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry Y.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"E00001","doi-asserted-by":"crossref","unstructured":"Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. a distinctive type of B-cell lymphoma. Cancer. 1983;52:1410-1416.","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"E00002","unstructured":"Jaffe ES, Harris NL, Stein H, et al, eds. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001. World Health Organization Classification of Tumours."},{"key":"E00003","doi-asserted-by":"crossref","unstructured":"Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, et al. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991;338:1175-1176.","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"E00004","doi-asserted-by":"crossref","unstructured":"Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575-577.","DOI":"10.1016\/0140-6736(93)91409-F"},{"key":"E00005","unstructured":"Bayerdorffer E, Neubauer A, Rudolph B, et al. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group. Lancet. 1995;345:1591-1594."},{"key":"E00006","doi-asserted-by":"crossref","unstructured":"Morgner A, Miehlke S, Fischbach W, et al. Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection. J Clin Oncol. 2001;19:2041-2048.","DOI":"10.1200\/JCO.2001.19.7.2041"},{"key":"E00007","doi-asserted-by":"crossref","unstructured":"Wotherspoon AC, Pan LX, Diss TC, et al. Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer Genet Cytogenet. 1992;58:35-38.","DOI":"10.1016\/0165-4608(92)90130-Z"},{"key":"E00008","unstructured":"Brynes RK, Almaguer PD, Leathery KE, et al. Numerical cytogenetic abnormalities of chromosomes 3, 7, and 12 in marginal zone B-cell lymphomas. Mod Pathol. 1996;9:995-1000."},{"key":"E00009","unstructured":"Horsman D, Gascoyne R, Klasa R, et al. t(11;18)(q21;q21.1): a recurring translocation in lymphomas of mucosa-associated lymphoid tissue (MALT)? Genes Chromosomes Cancer. 1992;4:183-187."},{"key":"E00010","doi-asserted-by":"crossref","unstructured":"Auer IA, Gascoyne RD, Connors JM, et al. t(11;18)(q21;q21) is the most common translocation in MALT lymphomas. Ann Oncol. 1997;8:979-985.","DOI":"10.1023\/A:1008202303666"},{"key":"E00011","unstructured":"Ott G, Katzenberger T, Greiner A, et al. The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin's lymphomas of the mucosa-associated lymphoid tissue (MALT-) type. Cancer Res. 1997;57:3944-3948."},{"key":"E00012","doi-asserted-by":"crossref","unstructured":"Akagi T, Motegi M, Tamura A, et al. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene. 1999;18:5785-5794.","DOI":"10.1038\/sj.onc.1203018"},{"key":"E00013","doi-asserted-by":"crossref","unstructured":"Levine EG, Arthur DC, Machnicki J, et al. Four new recurring translocations in non-Hodgkin lymphoma. Blood. 1989;74:1796-1800.","DOI":"10.1182\/blood.V74.5.1796.1796"},{"key":"E00014","doi-asserted-by":"crossref","unstructured":"Motegi M, Yonezumi M, Suzuki H, et al. API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products. Am J Pathol. 2000;156:807-812.","DOI":"10.1016\/S0002-9440(10)64948-6"},{"key":"E00015","doi-asserted-by":"crossref","unstructured":"Dierlamm J, Baens M, Stefanova-Ouzounova M, et al. Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes. Blood. 2000;96:2215-2218.","DOI":"10.1182\/blood.V96.6.2215"},{"key":"E00016","doi-asserted-by":"crossref","unstructured":"Ye H, Liu H, Attygalle A, et al. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma. Blood. 2003;102:1012-1018.","DOI":"10.1182\/blood-2002-11-3502"},{"key":"E00017","doi-asserted-by":"crossref","unstructured":"Inagaki H, Okabe M, Seto M, et al. API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens. Am J Pathol. 2001;158:699-706.","DOI":"10.1016\/S0002-9440(10)64012-6"},{"key":"E00018","doi-asserted-by":"crossref","unstructured":"Gabert J, Beillard E, van der Velden VH, et al. Standardization and quality control studies of \"real-time\" quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia: a Europe Against Cancer program. Leukemia. 2003;17:2318-2357.","DOI":"10.1038\/sj.leu.2403135"},{"key":"E00019","doi-asserted-by":"crossref","unstructured":"Remstein ED, James CD, Kurtin PJ. Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas. Am J Pathol. 2000;156:1183-1188.","DOI":"10.1016\/S0002-9440(10)64988-7"},{"key":"E00020","doi-asserted-by":"crossref","unstructured":"Huang X, Zhang Z, Liu H, et al. t(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients. Hematol J. 2003;4:342-345.","DOI":"10.1038\/sj.thj.6200295"},{"key":"E00021","doi-asserted-by":"crossref","unstructured":"Kalla J, Stilgenbauer S, Schaffner C, et al. Heterogeneity of the API2-MALT1 gene rearrangement in MALT-type lymphoma. Leukemia. 2000;14:1967-1974.","DOI":"10.1038\/sj.leu.2401918"},{"key":"E00022","doi-asserted-by":"crossref","unstructured":"Fung CY, Grossbard ML, Linggood RM, et al. Mucosa-associated lymphoid tissue lymphoma of the stomach: long term outcome after local treatment. Cancer. 1999;85:9-17.","DOI":"10.1002\/(SICI)1097-0142(19990101)85:1<9::AID-CNCR2>3.0.CO;2-S"},{"key":"E00023","doi-asserted-by":"crossref","unstructured":"Sackmann M, Morgner A, Rudolph B, et al. Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group. Gastroenterology. 1997;113:1087-1090.","DOI":"10.1053\/gast.1997.v113.pm9322502"},{"key":"E00024","doi-asserted-by":"crossref","unstructured":"Schreuder MI, Hoeve MA, Hebeda KM, et al. Mutual exclusion of t(11;18)(q21;q21) and numerical chromosomal aberrations in the development of different types of primary gastric lymphomas. Br J Haematol. 2003;123:590-599.","DOI":"10.1046\/j.1365-2141.2003.04630.x"},{"key":"E00025","doi-asserted-by":"crossref","unstructured":"Dierlamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood. 1999;93:3601-3609.","DOI":"10.1182\/blood.V93.11.3601"},{"key":"E00026","doi-asserted-by":"crossref","unstructured":"Rosenwald A, Ott G, Stilgenbauer S, et al. Exclusive detection of the t(11;18)(q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas. Am J Pathol. 1999;155:1817-1821.","DOI":"10.1016\/S0002-9440(10)65499-5"},{"key":"E00027","doi-asserted-by":"crossref","unstructured":"Liu H, Ye H, Ruskone-Fourmestraux A, et al. t(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H pylori eradication. Gastroenterology. 2002;122:1286-1294.","DOI":"10.1053\/gast.2002.33047"},{"key":"E00028","doi-asserted-by":"crossref","unstructured":"Streubel B, Lamprecht A, Dierlamm J, et al. t(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood. 2003;101:2335-2339.","DOI":"10.1182\/blood-2002-09-2963"},{"key":"E00029","doi-asserted-by":"crossref","unstructured":"Murga Penas EM, Hinz K, Roser K, et al. Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT\/MALT1 in MALT lymphomas. Leukemia. 2003;17:2225-2229.","DOI":"10.1038\/sj.leu.2403122"},{"key":"E00030","doi-asserted-by":"crossref","unstructured":"Sanchez-Izquierdo D, Buchonnet G, Siebert R, et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Blood. 2003;101:4539-4546.","DOI":"10.1182\/blood-2002-10-3236"},{"key":"E00031","doi-asserted-by":"crossref","unstructured":"Wotherspoon AC, Soosay GN, Diss TC, et al. Low-grade primary B-cell lymphoma of the lung: an immunohistochemical, molecular, and cytogenetic study of a single case. Am J Clin Pathol. 1990;94:655-660.","DOI":"10.1093\/ajcp\/94.5.655"},{"key":"E00032","doi-asserted-by":"crossref","unstructured":"Willis TG, Jadayel DM, Du MQ, et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999;96:35-45.","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"E00033","doi-asserted-by":"crossref","unstructured":"Streubel B, Vinatzer U, Lamprecht A, et al. t(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia. 2005;19:652-658.","DOI":"10.1038\/sj.leu.2403644"},{"key":"E00034","doi-asserted-by":"crossref","unstructured":"Starostik P, Patzner J, Greiner A, et al. Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways. Blood. 2002;99:3-9.","DOI":"10.1182\/blood.V99.1.3"},{"key":"E00035","doi-asserted-by":"crossref","unstructured":"Remstein ED, Kurtin PJ, James CD, et al. Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways. Am J Pathol. 2002;161:63-71.","DOI":"10.1016\/S0002-9440(10)64157-0"},{"key":"E00036","doi-asserted-by":"crossref","unstructured":"Liu H, Ye H, Dogan A, et al. t(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10. Blood. 2001;98:1182-1187.","DOI":"10.1182\/blood.V98.4.1182"},{"key":"E00037","doi-asserted-by":"crossref","unstructured":"Iwano M, Okazaki K, Uchida K, et al. Characteristics of gastric B-cell lymphoma of mucosa-associated lymphoid tissue type involving multiple organs. J Gastroenterol. 2004;39:739-746.","DOI":"10.1007\/s00535-004-1382-1"},{"key":"E00038","doi-asserted-by":"crossref","unstructured":"Inagaki H, Nakamura T, Li C, et al. Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter pylori eradication and detection of API2-MALT1 fusion. Am J Surg Pathol. 2004;28:1560-1567.","DOI":"10.1097\/00000478-200412000-00003"},{"key":"E00039","doi-asserted-by":"crossref","unstructured":"Baens M, Maes B, Steyls A, et al. The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation. Am J Pathol. 2000;156:1433-1439.","DOI":"10.1016\/S0002-9440(10)65012-2"},{"key":"E00040","doi-asserted-by":"crossref","unstructured":"Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A, et al. Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy [letter]. Lancet. 2001;357:39-40.","DOI":"10.1016\/S0140-6736(00)03571-6"},{"key":"E00041","doi-asserted-by":"crossref","unstructured":"Nakamura T, Inagaki H, Seto M, et al. Gastric low-grade B-cell MALT lymphoma: treatment, response, and genetic alteration. J Gastroenterol. 2003;38:921-929.","DOI":"10.1007\/s00535-003-1234-4"},{"key":"E00042","doi-asserted-by":"crossref","unstructured":"Ho L, Davis RE, Conne B, et al. MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells. Blood. 2005;105:2891-2899.","DOI":"10.1182\/blood-2004-06-2297"}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajcp\/article-pdf\/126\/6\/931\/4988345\/ajcpath126-0931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T04:42:01Z","timestamp":1587444121000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article-lookup\/doi\/10.1309\/UNXJVAMV77JAM4FM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,12,1]]},"published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1309\/UNXJVAMV77JAM4FM"],"URL":"https:\/\/doi.org\/10.1309\/unxjvamv77jam4fm","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}