{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:34:50Z","timestamp":1771295690482,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We describe an especially aggressive case of cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) in a 42-year-old man with familial adenomatous polyposis who died with lung and brain metastases 17 months after thyroidectomy. The angioinvasive neoplasm combined a mixture of trabecular, solid, cribriform, and follicular patterns of growth with CD10+ morules. Follicles were devoid of colloid, and the nuclear features typical of PTC were present in some areas and missing in others. Tumor cells were positive for thyroid transcription factor-1 and, in 40% of the tumoral mass, also were positive for chromogranin and synaptophysin and were negative for thyroglobulin and calcitonin. Strong nuclear staining for \u03b2-catenin was found in all tumor cells, as was positivity for p53 and cyclin D1. In addition to the germline heterozygous APC Ex 2\u20133 duplication mutation, a somatic homozygous silent p.Thr1493Thr gene variant was found in the neoplastic cells along with RET\/PTC rearrangement. This tumor represents the first case of C-MV of PTC showing neuroendocrine differentiation.<\/jats:p>","DOI":"10.1309\/ajcp7uls0vsisbeb","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T02:15:17Z","timestamp":1229652917000},"page":"134-142","source":"Crossref","is-referenced-by-count":62,"title":["Cribriform-Morular Variant of Papillary Thyroid Carcinoma"],"prefix":"10.1093","volume":"131","author":[{"given":"Jos\u00e9","family":"Cameselle-Teijeiro","sequence":"first","affiliation":[{"name":"1Department of Pathology, Clinical University Hospital, Galician Health Service, Christie Hospital NHS Foundation Trust, Manchester, England"}]},{"given":"Lia P.","family":"Menasce","sequence":"additional","affiliation":[{"name":"2Departments of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, England"}]},{"given":"Beng K.","family":"Yap","sequence":"additional","affiliation":[{"name":"3Clinical Oncology, Christie Hospital NHS Foundation Trust, Manchester, England"}]},{"given":"Rovel J.","family":"Colaco","sequence":"additional","affiliation":[{"name":"3Clinical Oncology, Christie Hospital NHS Foundation Trust, Manchester, England"}]},{"given":"Patricia","family":"Castro","sequence":"additional","affiliation":[{"name":"4Institute of Molecular Pathology and Immunology, University of Santiago de Compostela, Santiago de Compostela, Spain"}]},{"given":"Ricardo","family":"Celestino","sequence":"additional","affiliation":[{"name":"4Institute of Molecular Pathology and Immunology, University of Santiago de Compostela, Santiago de Compostela, Spain"}]},{"given":"Clara","family":"Ru\u00edz-Ponte","sequence":"additional","affiliation":[{"name":"5Galician Public Foundation of Genomic Medicine, Genomic Medicine Group, CIBER-ER, University of Santiago de Compostela, Santiago de Compostela, Spain"}]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"4Institute of Molecular Pathology and Immunology, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"6Department of Pathology, Medical Faculty, University of Porto, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal."}]},{"given":"Manuel","family":"Sobrinho-Sim\u00f5es","sequence":"additional","affiliation":[{"name":"4Institute of Molecular Pathology and Immunology, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"6Department of Pathology, Medical Faculty, University of Porto, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal."},{"name":"7Department of Pathology, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal."}]}],"member":"286","published-online":{"date-parts":[[2009,1,1]]},"reference":[{"key":"2023011905195189000_b1-1310134","first-page":"120","article-title":"Familial adenomatous polyposis","volume-title":"Pathology and Genetics of Tumours of the Digestive System.","author":"Talbot","year":"2000"},{"key":"2023011905195189000_b2-1310134","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(81)90021-0","article-title":"Identification and characterization of the familial adenomatous polyposis coli gene","volume":"66","author":"Groden","year":"1991","journal-title":"Cell"},{"key":"2023011905195189000_b3-1310134","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1651562","article-title":"Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers","volume":"243","author":"Kinzler","year":"1991","journal-title":"Science"},{"key":"2023011905195189000_b4-1310134","first-page":"123","article-title":"Multiple primary malignancies arising in the rectum, brain, and thyroid: report of a case","volume":"49","author":"Crail","year":"1949","journal-title":"U S Nav Med Bull"},{"key":"2023011905195189000_b5-1310134","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1056\/NEJM196805092781908","article-title":"Association of thyroid carcinoma with Gardner\u2019s syndrome in siblings","volume":"278","author":"Camiel","year":"1968","journal-title":"N Engl J Med"},{"key":"2023011905195189000_b6-1310134","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/bjs.1800740517","article-title":"Adenomatous polyposis: an association with carcinoma of the thyroid","volume":"74","author":"Plail","year":"1987","journal-title":"Br J Surg"},{"key":"2023011905195189000_b7-1310134","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s003840050097","article-title":"Is screening for thyroid carcinoma indicated in familial adenomatous polyposis? 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