{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:28:35Z","timestamp":1781018915582,"version":"3.54.1"},"reference-count":0,"publisher":"Indian Orthopaedic Research Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Jocr"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Introduction: Total knee arthroplasty (TKA) is associated with significant perioperative blood loss, often necessitating blood transfusions. Tranexamic acid (TXA), an antifibrinolytic agent, has been shown to reduce bleeding effectively. This study evaluated the efficacy and safety of intravenous TXA in reducing perioperative blood loss in patients undergoing primary unilateral TKA.\n\nMaterials and Methods: This prospective randomised controlled trial included 60 patients with Kellgren-Lawrence Grade 3 or 4 osteoarthritis undergoing primary unilateral TKA at a tertiary care centre. Patients were randomised into two groups: The TXA group (n = 30) received 1 g intravenous TXA before tourniquet release, while the control group (n = 30) received normal saline. Outcome measures included intraoperative blood loss, postoperative drain output, haemoglobin changes, and transfusion requirements.\n\nResults: The TXA group demonstrated significantly lower intraoperative blood loss (205.33 vs. 305.67 mL, P &lt; 0.001), total drain output (185.00 vs. 298.33 mL, P &lt; 0.001), and proportional haemoglobin loss (14.19% vs. 19.98%, P &lt; 0.001). Transfusion requirements were significantly reduced in the TXA group (6.67% vs. 26.67%, P = 0.039). No thromboembolic complications were observed in either group.\n\nConclusion: Intravenous TXA significantly reduces perioperative blood loss and transfusion requirements in TKA without increasing thromboembolic risk, supporting its routine use in blood conservation protocols.\n\nKeywords: Tranexamic acid, total knee arthroplasty, blood loss, blood transfusion, antifibrinolytic.<\/jats:p>","DOI":"10.13107\/jocr.2026.v16.i06.7382","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:35:50Z","timestamp":1781015750000},"page":"57-61","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Tranexamic Acid in Reducing Blood Loss and Transfusion Requirements in Primary Total Knee Arthroplasty: A Prospective Comparative Study"],"prefix":"10.13107","volume":"16","author":[{"given":"C","family":"Yogesh","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Supreeth","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Sonth","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N Rachan","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ambareesh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Vishwanath","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5271","published-online":{"date-parts":[[2026]]},"container-title":["Journal of Orthopaedic Case Reports"],"original-title":[],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:35:52Z","timestamp":1781015752000},"score":1,"resource":{"primary":{"URL":"https:\/\/jocr.co.in\/wp\/2026\/06\/efficacy-of-tranexamic-acid-in-reducing-blood-loss-and-transfusion-requirements-in-primary-total-knee-arthroplasty-a-prospective-comparative-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.13107\/jocr.2026.v16.i06.7382","relation":{},"ISSN":["2321-3817"],"issn-type":[{"value":"2321-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}