{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T09:05:15Z","timestamp":1789290315962,"version":"build-2803163510"},"reference-count":0,"publisher":"Indian Orthopaedic Research Group","issue":"9","content-domain":{"domain":["jocr.co.in"],"crossmark-restriction":true},"short-container-title":["Jocr"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Introduction:\nOsteosarcoma, the most prevalent malignant primary bone tumor in children and adolescents, can present formidable challenges when involving long segments of the humerus. Reconstruction options must balance oncological clearance with long-term limb function, particularly in skeletally immature patients.\n\nCase Report:\nWe report a case of a 15-year-old female diagnosed with high-grade osteosarcoma involving the proximal epiphysis and most of the diaphysis of the right humerus, sparing only the distal 3 cm. Following neoadjuvant chemotherapy, the patient underwent wide tumor excision and a novel hybrid limb-salvage reconstruction using a custom proximal prosthesis combined with biological reconstruction of the diaphysis via extracorporeal radiotherapy (ECRT). The tumor-bearing bone was irradiated with 50 Gy ex vivo and reimplanted, fixed to the preserved distal humerus with a locking plate. At 18-month follow-up, the patient remained disease-free, with radiographic evidence of graft incorporation and preserved elbow function.\n\nConclusion:\nThis case highlights the viability of combining prosthetic and biological methods in complex pediatric osteosarcoma, especially when distal joint preservation is possible. ECRT provides a cost-effective, anatomically compatible solution that maintains structural integrity, especially when used with proximal prosthetic support. This hybrid method represents an optimal limb-salvage strategy in selected pediatric cases involving long bone tumors.\n\nKeywords:\nOsteosarcoma , humeral neoplasms , extracorporeal radiotherapy , limb salvage , megaprosthesis<\/jats:p>","DOI":"10.13107\/jocr.2026.v16.i09.8098","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:19:37Z","timestamp":1788952777000},"page":"374-378","update-policy":"https:\/\/doi.org\/10.13107\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hybrid Prosthetic and Biological Reconstruction Using Extracorporeal Radiotherapy for Long-Segment Humeral Osteosarcoma: A Case Report"],"prefix":"10.13107","volume":"16","author":[{"given":"Prabodh","family":"Kantiwal","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Mohammed","family":"Adnan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Suhail","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manveer","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhi","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Trauma and Emergency (Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Khera","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5271","published-online":{"date-parts":[[2026]]},"container-title":["Journal of Orthopaedic Case Reports"],"original-title":[],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T08:45:22Z","timestamp":1789289122000},"score":1,"resource":{"primary":{"URL":"https:\/\/jocr.co.in\/wp\/2026\/09\/hybrid-prosthetic-and-biological-reconstruction-using-extracorporeal-radiotherapy-for-long-segment-humeral-osteosarcoma-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.13107\/jocr.2026.v16.i09.8098","relation":{},"ISSN":["2321-3817"],"issn-type":[{"value":"2321-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Research Article","name":"content_type","label":"Content Type"},{"value":"Yes","name":"crosschecked","label":"CrossChecked"},{"value":"Yes","name":"peer_reviewed","label":"Peer Reviewed"},{"value":"10.13107\/jocr.2026.v16.i09.8098","name":"published","label":"Published"},{"value":"Creative Commons Attribution","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},"group":{"name":"rights","label":"Rights"}}]}}