{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:22:44Z","timestamp":1789370564747,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of the successful use of donepezil for treatment of cognitive and noncognitive symptoms in a patient with dementia with Lewy bodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>An 86-year-old white woman with dementia was experiencing early-onset significant fluctuation of her cognitive status, functional impairment, visual hallucinations, aggression, and parkinsonism. She was initially diagnosed with Alzheimer disease and Parkinson's disease and prescribed donepezil 5 mg\/d and benztropine 1 mg twice daily. On reexamination of the case by a neurologist, the diagnoses were revised to dementia with Lewy bodies. The benztropine was discontinued, and donepezil was increased to 10 mg\/d. The patient's cognitive and functional status significantly improved, as did her visual hallucinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>This case supports previous reports of the marked responsiveness of patients with dementia with Lewy bodies to acetylcholinesterase inhibitors. This may be explained by the marked cholinergic deficit observed in patients with dementia with Lewy bodies and the evidence linking cognitive as well as noncognitive symptoms to this deficit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The present case suggests that patients with dementia with Lewy bodies respond well to acetylcholinesterase inhibitors. Controlled trials are necessary to further define the role of these drugs for this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1345\/aph.10192","type":"journal-article","created":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T17:09:48Z","timestamp":1054660188000},"page":"202-205","source":"Crossref","is-referenced-by-count":43,"title":["Successful Use of Donepezil for the Treatment of Dementia with Lewy Bodies"],"prefix":"10.1177","volume":"35","author":[{"given":"Carlos H","family":"Rojas-Fernandez","sequence":"first","affiliation":[{"name":"Carlos H Rojas-Fernandez PharmD, Assistant Professor of Pharmacy Practice, School of Pharmacy, Department of Pharmacy Practice, Texas Tech University\u2014Health Sciences Center\u2014Amarillo, 1300 Coulter, Amarillo, TX 79106-1712, FAX 806\/356-4018"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,2,1]]},"reference":[{"key":"bibr1-aph.10192","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"bibr2-aph.10192","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.10.795.31555"},{"key":"bibr3-aph.10192","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610298005341"},{"key":"bibr4-aph.10192","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb00217.x"},{"key":"bibr5-aph.10192","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00002093-199706001-00003","volume":"11","author":"Reisberg B","year":"1997","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"bibr6-aph.10192","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90966-0"},{"key":"bibr7-aph.10192","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199901)14:1<69::AID-GPS888>3.0.CO;2-C"},{"key":"bibr8-aph.10192","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1512"},{"key":"bibr9-aph.10192","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(200004)15:4<338::AID-GPS119>3.0.CO;2-U"},{"key":"bibr10-aph.10192","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(200005)15:5<387::AID-GPS131>3.0.CO;2-9"},{"key":"bibr11-aph.10192","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800170032006"},{"key":"bibr12-aph.10192","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199819060-00004"},{"key":"bibr13-aph.10192","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.157.1.4"},{"key":"bibr14-aph.10192","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199812000-00011"},{"key":"bibr15-aph.10192","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.4.876"},{"key":"bibr16-aph.10192","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01361-7"},{"key":"bibr17-aph.10192","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.3.324-a"},{"key":"bibr18-aph.10192","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550160091022"},{"key":"bibr19-aph.10192","doi-asserted-by":"publisher","DOI":"10.1159\/000051193"},{"key":"bibr20-aph.10192","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1222"},{"key":"bibr21-aph.10192","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.11.1388"},{"key":"bibr22-aph.10192","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.902"},{"key":"bibr23-aph.10192","doi-asserted-by":"publisher","DOI":"10.1159\/000026219"},{"key":"bibr24-aph.10192","first-page":"S131","volume":"13","author":"Gorelick PB","year":"1999","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"bibr25-aph.10192","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199912010-00004"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1345\/aph.10192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:29Z","timestamp":1777374269000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1345\/aph.10192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":25,"aliases":["10.1345\/1542-6270(2001)035<0202:suodft>2.0.co;2"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1345\/aph.10192"],"URL":"https:\/\/doi.org\/10.1345\/aph.10192","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}